Metastasis Targeted Therapies in Renal Cell Cancer
Journal Title: Üroonkoloji Bülteni - Year 2018, Vol 17, Issue 1
Abstract
Metastatic renal cell cancer is a malignant disease and its treatment has been not been described clearly yet. These patients are generally symptomatic and resistant to current treatment modalities. Radiotherapy, chemotherapy, and hormonal therapy are not curative in many of these patients. A multimodal approach consisting of cytoreductive nephrectomy, systemic therapy (immunotherapy or targeted molecules), and metastasectomy has been shown to be hopeful in prolonging the survival and improving the quality of life in some of these patients. Patients with oligometastatic disease and good performance status have better results following this multimodal approach. Cytoreductive nephrectomy and adjuvant/neoadjuvant systemic therapies (immunotherapy, targeted therapy) have been investigated for treatment options of metastatic renal cancer patients. After better understanding of the genetic basis and the molecular biology of the renal cell carcinoma, targeted molecular therapies and immunotherapies have emerged as more efficient alternative therapy options with moderate adverse effects. Metastasectomy in some of these patients improves survival and quality of life, especially in those with lung and bone metastases. In this review we will summarize treatment options for metastatic renal cancer patients.
Authors and Affiliations
K. Fehmi Narter, Bora Özveren
Keywords
Related Articles
- EP ID EP379708
- DOI 10.4274/uob.962
- Views 126
- Downloads 0
Long-Term Outcomes of Patients Who Underwent Ureterocutaneostomy
Objective: Ureterocutaneostomy (UCS) is a urinary diversion (UD) method which is used rarely in a carefully selected patient group. In this study, we aimed to present the data and long-term outcomes of patients who under...
Incidental Amyloidosis of the Seminal Vesicle: A Case Report and Review of the Literature
With a widely usage of prostate specific antigen (PSA) testing as a screening tool, number of prostate biopsy procedures and number of biopsy cores are increased because of the negative pathology results. As a result of...
The Role of Imaging in Testicular Cancer Diagnosis, Staging and Follow-up
Although testicular cancer is relatively rare and accounting for approximately 1-1.5% of all cancers in men, it is the most frequent malignancy in young men. Testicular cancer can manifest in a variety of ways. A painles...
Information about Prostate Cancer for Urologist: Ga-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography Scintigraphy
Recently, prostate-specific membrane antigen (PSMA), a glutamate carboxypeptidase II enzyme, has transformed intoan excited radiopharmaceutical agent as a result of radiolabeling of small peptides that are developed for...
Controversies in Radical Cystectomy: Meta-Analysis and Systemic Comparison of Open Surgery with Laparoscopic and Robotic Surgery
Open radical cystectomy (ORC) is the standard treatment modality in high-risk non-muscle-invasive and invasive bladder carcinoma. Although it has some advantages, oncologic outcomes of ORC are associated with high morbid...