Method Development and Validation for Simultaneous Estimation of Rizatriptan Benzoate and Naproxen Sodium by UV Spectrophotometric Method
Journal Title: IP Archives of Cytology and Histopathology Research - Year 2016, Vol 3, Issue 1
Abstract
A Simple, validated, accurate and precise simultaneous UV Spectrophotometric method has been developed for the simultaneous estimation of Rizatriptan Benzoate (RIZ) and Naproxen Sodium (NAP) in pharmaceutical dosage form. Rizatriptan Benzoate exhibits absorption maximum at 282.9nm and Naproxen Sodium shows absorption maximum at 261.8nm in methanol. The Beer’s law obeyed the concentration range of 5-30µg/ml for RIZ and NAP. Mean recovery of 100.25% for RIZ and 99.2%5 for NAP respectively signifies the accuracy of the method. This method can be used for the routine simultaneous estimation of RIZ and NAP in pharmaceutical dosage forms.
Authors and Affiliations
Prasanthi T, Varshini K, Mahaboobunnisa Md, Chandini NB, Apurupa P, Latha PM, Lakshmana Rao A
Keywords
Related Articles
- EP ID EP240390
- DOI -
- Views 98
- Downloads 0
The study of vesicobullous skin lesions by Tzanck smear cytology
Vesicobullous lesion of skin and mucosa is commonly seen in clinical practice of dermatology Tzanck smear preparation is simple sensitive rapid and inexpensive procedure that has capacity to reveal the cytomorphological...
Pure medullary cancer Vs IDC with medullary like features of Breast
Pure medullary cancer of the breast is uncommon subtype of infiltrating duct carcinoma (IDC) comprising 3-5% of all breast neoplasms. Newer and specific nomenclature of medullary carcinoma is basal-like breast carcinoma...
Histopathology of endometrium in dysfunctional uterine bleeding
Introduction: Abnormal uterine bleeding is a common condition affecting women of reproductive age that has significant social and economic impact. Dysfunctional uterine bleeding (DUB) is defined as abnormal uterine bleed...
Prospective study of Meningioma & diagnostic validity of MIB-1 index in grading of meningioma
Background: Meningioma is one of indolent neoplasm. Meningiomas may make their appearance in childhood or adolescence, but most are encountered in middle or later adult life. Females are affected more commonly than males...
Primary malignant melanoma of uterine cervix in a young female - Report of a rare case
Malignant melanoma MM of gynaecological tract represents about 2 cases of all melanomas Most of the gynaecologic tract melanomas are reported in vulva and vagina Malignant melanoma of uterine cervix is extremely rare and...