Method Development and Validation for Simultaneous Estimation of Rizatriptan Benzoate and Naproxen Sodium by UV Spectrophotometric Method
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2016, Vol 3, Issue 1
Abstract
A Simple, validated, accurate and precise simultaneous UV Spectrophotometric method has been developed for the simultaneous estimation of Rizatriptan Benzoate (RIZ) and Naproxen Sodium (NAP) in pharmaceutical dosage form. Rizatriptan Benzoate exhibits absorption maximum at 282.9nm and Naproxen Sodium shows absorption maximum at 261.8nm in methanol. The Beer’s law obeyed the concentration range of 5-30µg/ml for RIZ and NAP. Mean recovery of 100.25% for RIZ and 99.2%5 for NAP respectively signifies the accuracy of the method. This method can be used for the routine simultaneous estimation of RIZ and NAP in pharmaceutical dosage forms.
Authors and Affiliations
Prasanthi T, Varshini K, Mahaboobunnisa Md, Chandini NB, Apurupa P, Latha PM, Lakshmana Rao A
Keywords
Related Articles
- EP ID EP240417
- DOI -
- Views 166
- Downloads 0
A retrospective study to determine adverse effects of anti-retroviral agents in tertiary care hospital in Central India
Introduction: The introduction of Highly Active Anti-retroviral Therapy (HAART) has led to significant reduction in AIDS related morbidity & mortality. The majority of drugs available today are costly & have serious adve...
To compare the safety and efficacy of diacerein and oxaceprol in the management of grade I & II osteoarthritis of knee
Introduction Diacerein and oxaceprol are frequently used for the treatment of GradeI II osteoarthritis of knees Diacerein acts by blocking the action of interleukin1 whereas oxaceprol prevents leukocyte infiltration in...
Evaluation of antidepressant effects of rosuvastatin in male albino mice by tail suspension model
Objective: To evaluate the antidepressant activity of Rosuvastatin in male albino mice. Method: Thirty male swiss albino mice were selected for tail suspension model. There were five groups and each group had six animals...
Attenuation of Sub Acute Inflammation by Ethanol Extract of Clerodendrum viscosum Linn. Leaves in Wistar Albino Rats
Inflammation is a pathological response of vascular tissue for harmful stimuli caused by injury, infection, environmental agents, malignancy and cellular changes. In our study we have tried to evaluate attenuation effect...
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Paracetamol and Tramadol Hydrochloride
A simple and rapid RP-HPLC method has been developed for the simultaneous estimation of paracetamol and tramadol hydrochloride. The chromatographic analysis was carried out on an Enable C18 column (250×4.6 mm i.d., 5µm)...