Method Development and Validation for Simultaneous Estimation of Rizatriptan Benzoate and Naproxen Sodium by UV Spectrophotometric Method
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2016, Vol 3, Issue 1
Abstract
A Simple, validated, accurate and precise simultaneous UV Spectrophotometric method has been developed for the simultaneous estimation of Rizatriptan Benzoate (RIZ) and Naproxen Sodium (NAP) in pharmaceutical dosage form. Rizatriptan Benzoate exhibits absorption maximum at 282.9nm and Naproxen Sodium shows absorption maximum at 261.8nm in methanol. The Beer’s law obeyed the concentration range of 5-30µg/ml for RIZ and NAP. Mean recovery of 100.25% for RIZ and 99.2%5 for NAP respectively signifies the accuracy of the method. This method can be used for the routine simultaneous estimation of RIZ and NAP in pharmaceutical dosage forms.
Authors and Affiliations
Prasanthi T, Varshini K, Mahaboobunnisa Md, Chandini NB, Apurupa P, Latha PM, Lakshmana Rao A
Keywords
Related Articles
- EP ID EP240417
- DOI -
- Views 159
- Downloads 0
Awareness of Adverse Drug Reaction Monitoring and Practice among Student Nurses
Background: Adverse drug reactions (ADRs) accounts for significant morbidity and mortality. Nurses will play a vital role in monitoring and reporting of ADRs. To monitor and voluntarily report the ADR the nursing student...
Ajuga bracteosa: A central Himalayan plant shows potent hypoglycemic effect in rats
Background: In the present study, a central Himalayan herb; Ajuga bracteosa Wall. ex Benth. (Neelkanthi, Ratapaati) was investigated for the probable hypoglycemic activity underlying in it. Material and Method: The hydro...
Solubility Enhancement of Poorly Water Soluble Drug Aceclofenac
Solid dispersion was aim for increasing solubility and bioavailability of poorly aqueous soluble drug aceclofenac (ACE). Solid dispersion of drug aceclofenac (NSAID) was prepared by using different polymers i.e. Polaxome...
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Paracetamol and Tramadol Hydrochloride
A simple and rapid RP-HPLC method has been developed for the simultaneous estimation of paracetamol and tramadol hydrochloride. The chromatographic analysis was carried out on an Enable C18 column (250×4.6 mm i.d., 5µm)...
Analgesic activity of lagenaria siceraria root extract by tail flick method in albino mice
Introduction Analgesics relieve pain which otherwise can cause distress and suffering But analgesics like NSAIDs and opioids can cause side effects like gastric irritation tolerance and dependence Hence it is essential t...