METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF BREXPIPRAZOLE IN DRUG SUBSTANCE BY RP-HPLC METHOD
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract Analytical method was developed for the estimation of Brexpiprazole drug substance by liquid chromatography. The chromatographic separation was achieved on C18 column (Inertsil ODS 3V 150*4.6, 5um) at ambient temperature .the separation achieved employing a mobile phase consists of 0.1%v/v Formic acid in water: Methanol (35:65). The flow rate was 0.8 ml/ minute and ultra violet detector at 315nm. The average retention time for Brexpiprazole found to be 2.27 min the proposed method was validated for selectivity, precision, linearity and accuracy. All validation parameters were within the acceptable range. The assay methods were found to be linear from 50-150μg/ml for Brexpiprazole.
Authors and Affiliations
A. Sravani, CH. Naga Durga, Uppalapati Divya, CH. Suneetha, P. Suresh, Dr B Tirumaleswara Rao, Dr. Challa Sudheer*
Keywords
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