METOPROLOL-INDUCED LIVER INJURY AND THE HEPATOPROTECTIVE ROLE OF VITAMIN E IN RABBITS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 4
Abstract
Objective: This study aims to investigate the hepatotoxicity of metoprolol and find a prophylactic way to protect the liver through the use of Vitamin E. Methods: A total of 18 male rabbits were divided randomly into three groups, with six in each group. Group I (control) received corn oil, Group II was treated with metoprolol (20 mg/kg), and Group III was treated with Vitamin E (175 mg/kg) 30 min before metoprolol treatment. All treatments were given orally and daily for 14 days; animals were sacrificed at day 15. Biochemical parameters were estimated, and the liver was used for histopathological examinations. Results: Histopathological changes of liver injury were found in all metoprolol-treated rabbits, while these changes were minimized in all rabbits who were given Vitamin E. Serum liver function tests and malondialdehyde (MDA) were significantly elevated after metoprolol treatment and returned close to the control value on prior treatment with Vitamin E. Serum MDA, aspartate aminotransferase, and alanine aminotransferase were significantly decreased following treatment with Vitamin E. Conclusion: Vitamin E may have a hepatoprotective effect against metoprolol-induced liver injury in rabbits.
Authors and Affiliations
MAYSAA BANAY ZUBAIRI
Keywords
Related Articles
- EP ID EP604670
- DOI -
- Views 113
- Downloads 0
P-SELECTIN GLYCOPROTEIN LIGAND-1 GENE POLYMORPHISMS IN SUDANESE PREGNANT WOMEN WITH THROMBOSIS
Objectives: In this study we aimed to investigate whether P-selectin gene polymorphism is associated with thrombosis in Sudanese pregnant women in Khartoum state.Methods: After informed consent, 96 Sudanese pregnant wome...
APPLICATION OF CENTRAL COMPOSITE DESIGN AND RESPONSE SURFACE METHODOLOGY FOR OPTIMIZATION OF METAL ORGANIC FRAMEWORK: NOVEL CARRIER FOR DRUG DELIVERY
Objective: The aim of the present study is to optimize the synthesis method of metal-organic framework (MOF) for high yield and larger surface area with minimum size for efficient drug loading. Materials and Methods: Ma...
MOMORDICA CHARANTIA NANO DRY POWDER ORAL FORMULATION IN CONTROLLING HISTAMINE-INDUCED BRONCHOSPASM
Objective: Momordica charantia (MC) (bitter gourd) is known traditionally to possess medicinal values. This edible vegetable is known for its anti-inflammatory properties and has been studied for its bronchospasm prevent...
EFFECT OF MANGOSTEEN EXTRACT ON NEUROINFLAMMATION IN RAT MODEL OF ACUTE TRAUMATIC BRAIN INJURY
Objective: Traumatic brain injury (TBI) is one of the major health problems regarding morbidity and mortality, especially in productive ages. Following primary injury, there is a secondary insult, resulting in oxidative...
DFT Calculations and In Silico Studies on the Schiff base derivatives with Antibacterial Activities
Abstract The heterocyclic Schiff bases (N1Z,N4Z)-N1,N4-bis(3,4-methoxyphenyl)methylidene) benzene-1,4-diamine (1), (N1Z,N4Z)-N1,N4-bis(4-bromobenzyliden...