Micro Total Analysis System Application for Biomedicals: A Mini-Review
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 12, Issue 4
Abstract
Recently, the microfluidic system is one of the most trending research topics in the world due to its unique characteristics and great advantages. The present mini-review deals with the application of micro total analysis system for the biomedical fields, such as in situ detection, enrichment, imaging, and quantification of biomolecules and cell. The recent progress of the microfluidic system on cancer, tumor, HIV, diabetes, malaria and tuberculosis was displayed.Microfluidic is a new field which employing reactor channels in micrometer dimensions [1,2]. The first primitive microfluidic study was introduced by Hodgson and Charles in 1963. They investigated the slug flow between water and oil in pipe and studied for their flow pattern, droplet velocity and pressure drop inside the pipe [3]. In 2001, Burn and Ramshaw reported the mass transfer phenomena of acetic acid from the aqueous phase to the kerosene as the dispersed phase [4]. From 2001, a lot of papers related to microfluidic study and application have been published. Even though this system called as micro total analysis device, it is possible to set up a system that includes sampling, pre-treatment, sensor/detection, quantification and imaging process as called as micro total analysis system or lab-on-chip system [5]. This unique and marvelous application is possible because of the great advantages from employing the microfluidic system. The advantages from employing microfluidic system are portable device, tiny chemical reagents are required, save energy and space, rapid and easy control process and low-risk operation [6]. Therefore, great interests are on the microfluidic field due to its unique characteristics and phenomena. Microfluidic system has been widely applied in metal extraction, organic synthesis and biomedical fields such as rapid and in situ detection and monitoring of biochemicals, enzymatic reaction, drug screening and delivery, cell assay, protein crystallization, and so on [7-14]. The present mini review is focused on micro total analysis system for biomedical application and the progress on the recent researches are briefly discussed.Cancer is one of the most concerned diseases in the world. Many researchers are trying to make significant findings to detect and treat the cancer cells, however, the conventional method is time-consuming, low validity, and lack appropriate control [15]. Microfluidic system offers a real-time and reliable analysis to detect the cancer cell in the in vitro and in vivo study [16]. Bhagat, et al. reported the isolation of cancer cell from the blood by employing lift force-induced cell separation technique in well-design microchannels. By using this technique, the recovery percentage of circulating tumor cell reached 81% with 20 times sample dilution and 0.400 mL min-1 sample flow rate (around 108 cellsmin-1), which is rapid and efficient separation compared with conventional technique [17]. On the other hand, microfluidic applications on tumor cell were also reported. Moore, et al. evaluated a multiplexed microfluidic system to monitor the immune-tumor interactions. The established system is able for imaging of autologous TILs and tumor fragments in a real-time analysis for several days [18].
Authors and Affiliations
Yehezkiel Steven Kurniawan
Keywords
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- EP ID EP593811
- DOI 10.26717/BJSTR.2019.12.002294
- Views 147
- Downloads 0
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