MICROALBUMINURIA IN NON-PROTEINURIC DIABETIC PATIENTS AND ITS CORRELATION WITH DIABETIC RETINOPATHY AND NEUROPATHY- A CROSS-SECTIONAL STUDY IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 63
Abstract
BACKGROUND Diabetes is a stage of persistent hyperglycaemia due to absolute or relative deficiency of insulin. Microalbuminuria is often the first sign of renal dysfunction in diabetes. Microalbuminuria is defined as the urinary excretion of albumin of 20-200 µg/min. or 30-300 mg/24 hours with a negative dipstick test. The aim of the study is to evaluate the frequency of MAU amongst studied population of diabetic patients of different age group, sex, duration and types of diabetes. The study was also used to establish relationship of MAU with serum cholesterol, serum creatinine, retinopathy and diabetic neuropathy. MATERIALS AND METHODS The study was conducted in BJMC, Civil Hospital, Ahmedabad over the period of two years on 91 admitted cases of diabetes lying in the age group of 15-75 years. The study was restricted to use of Micral II strips manufactured by the Boehringer Mannheim India Limited. It is based on the principle of immunologic detection of human albumin by means of soluble antibody-gold conjugate. First morning sample was used for the study. MAU is positive when there is colour change ranging from peach (20-50 mg/L) to light pink (50-100 mg/L) to dark pink (>100 mg/L), corresponding to increasing values of MAU. RESULTS In the present study conducted amongst 91 diabetic patients, 57% of the patients showed Micral positivity with male to female ratio of 2.25:1. Statistically significant correlation was seen between microalbuminuria and duration of diabetes, value of serum creatinine, serum cholesterol and serum protein respectively. Out of 36% patients with duration of diabetes <2 years, approximately one third tested positive for microalbuminuria. As the duration of diabetes advances from 10 years to more than 20 years, number of positive cases rises from 72% to 100%. Of the 48 patients with evidence of diabetic retinopathy, 60% showed positive results for microalbuminuria. CONCLUSION We investigated microalbuminuria in diabetes patients to emphasise the need for routine screening and better control of risk factors preceding ESRD.
Authors and Affiliations
Sujata Raychaudhuri, Nimisha Sharma, Deepshikha Rana
Keywords
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- EP ID EP231446
- DOI 10.14260/Jemds/2017/996
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