Abstract

These modern days we have many problem and unsolved question about tablets and liquid preparation for treatment of chronic fungal diseases. To overcome all such problems semisolid preparations especially gels were came into picture. Gels are more prominent for delivering the drug to the site of action on skin. But the major problem with the gel is they are aqueous in nature and they cannot incorporate lipophilic drugs in them, and unfortunately most of the antifungal drugs are lipophilic in nature. So to solve the issue oil in water type emulsion is prepared. Then emulsion mixed with aqueous gel and a new drug delivery system emulgel is formed. The microemulgel is prepared by reducing the globule size of the emulsion (less then 200nm) so that drug particle can easily penetrate through the stratum corneum. In spite of penetration the microemulgel for skin has several other advantages like longer shelf-life, easily removable, self administration etc. It also has several favourable formulation advantages like easily spreadable, non grease, thixotropic, transparent, non-staining, and bio-friendly. This novel drug delivery system can use as targeted delivery for treatment of superficial fungal infection. The Novel vesicular drug delivery system also can be used for delivering analgesic, Anti-inflammatory, anti-acne, anti-viral drugs. This review gives detailed information about fungal diseases and their causative agents and properties, formulation consideration, various method of preparation, advantages, application and Characterization of microemulsion based gel for drug delivery system.

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