MICROEMULSION FORMULATION OF ALOE VERA GEL AND APIUM GRAVEOLENS ETHANOL EXTRACT FOR OPTIMIZING HAIR GROWTH PROMOTION
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 4
Abstract
ABSTRACTObjective: Follicular penetration of hair promotion substances to the bulge region is needed to potentiate cell proliferation and hair shaft lengthening.Nano-size globule is one of important delivery systems applied for hair follicle targeting. This research aims to explore the effect of microemulsionon hair promoting activities of a mixture of hydrophilic substances of Aloe vera gel and semipolar substances of Apium graveolens ethanolic extract.Methods: The clear water in oil (W/O) and oil in water (O/W) microemulsions were developed by constructing phase diagram of various ratiosof Crodamol GTCC, Croduret 50 SS, glycerin/alcohol, and water. A. vera (1%) and celery extract (2%) were incorporated during microemulsionpreparation. The microemulsions were applied over shaved skin areas of the backs of Wistar rats, and the average length of 10 hair samples wasdetermined at day 7, 14, and 21 compared to the un-treated area. The weight of hair/cm2 area was also analyzed at day 21. Hair growth promotion ofthe microemulsions was compared to the other groups of rats applied by A. vera in water (AVW), celery extract in water and oil (CEW and CEO), andcombination of A. vera and celery extract in water (AVCEW).Result: The W/O and O/W microemulsion consisted of globules at the average size of 61.7 and 81.5 nm, respectively, which showed stable sizefollowing six cycles of freeze-thaw. The W/O microemulsion increased hair growth dramatically started at day 7 (220%) and day 14 (275%) andslowed-down at day 21 (163%) with similar profile shown by AVW (74.5, 65.8, 31.7%, respectively). On the contrary, the hair growth promotion ofO/W microemulsion delayed to day 14 but maintained till day 21 (143.7, 214.5, 171.9 at day 7, 14, and 21, respectively) with similar profile shownby CEW and CEO. Hair densities were also doubled in the areas treated by both microemulsion types than in the areas treated by a combination ofAVCEW in water.Conclusion: Incorporation of hydrophilic and semipolar substances of hair growth promoter in nano-size globules of W/O and O/W microemulsionslead to pilosebaceous targeting and optimize the growth promotion activities.Keywords: Aloe vera, Apium graveolens, Water in oil microemulsion, Oil in water microemulsion, Hair growth, Pilosebaceous.
Authors and Affiliations
Jessie Sofia Pamudji
Keywords
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