MicroRNA-21 as a Potential Biomarker for Colorectal Cancer Diagnosis: A Meta-analysis
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 17, Issue 8
Abstract
Aims: Colorectal cancer (CRC) occupies an important position in the morbidity and mortality constitution of malignancies. In recent years, mounting literature has reported about the upregulating expression of microRNA-21 in blood and stool of CRC patients, which suggested that microRNA-21 may become a novel potential biomarker for CRC. Consequently, this meta-analysis was designed to systematically review the values of microRNA-21 in CRC diagnosis. Methodology: Databases, including Cochrane library, PubMed, EMbase, Google Scholar, and Chinese National Knowledge Infrastructure, were scanned to retrieve relevant articles focusing on microRNA-21 in CRC diagnosis. Articles were then filtered according to the PRISMA statement and assessed by quality assessment of diagnosis accuracy studies-2. Sensitivity (SEN), specificity (SPE), positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio (DOR) were pooled using fixed-effects model or random-effects model. Summary receiver operating characteristic (SROC) curve and area under the curve (AUC) were used to estimate the overall diagnostic performance. Results: A total of 15 studies, comprising 1268 CRC patients and 910 healthy controls, were enrolled in this meta-analysis. For serum miR-21, the pooled DOR, SEN, and SPE were 13.97 (95% CI: 8.44–23.11), 0.73 (95% CI: 0.69–0.77), and 0.83 (95% CI: 0.76–0.89), respectively; for plasma miR-21, the pooled DOR, SEN, and SPE were 8.03 (95% CI: 3.30–19.52), 0.67 (95% CI: 0.60–0.73), and 0.76 (95% CI: 0.69–0.81), respectively; and for fecal miR-21, the pooled DOR, SEN, and SPE were 7.06 (95% CI: 2.17–22.95), 0.33 (95% CI: 0.28–0.37), and 0.91 (95% CI: 0.88–0.93), respectively. Moreover, the AUC values of serum, plasma, and fecal miR-21 in CRC diagnosis were 0.8701, 0.8295, and 0.6742, respectively. Conclusion: Blood miR-21 demonstrates good diagnostic performance, and serum samples are better than plasma samples in CRC diagnosis. For fecal miR-21, the sensitivity is unsatisfactory, but the specificity is favorable in predicting CRC patients.
Authors and Affiliations
Chao-Hui Zhen, Guo-Jun Yao, Yan Tan, Lu Yang, Xiao-Fang Yu, Fu-Rong Li
Keywords
Related Articles
- EP ID EP341933
- DOI 10.9734/BJMMR/2016/27261
- Views 55
- Downloads 0
Vitamin D Status Appears Unrelated to Fractures in Patients with Chronic Kidney Disease
Background: Although lack of Vitamin D is widespread in chronic kidney disease, data is scarce in the role Vitamin D may play in fractures in such cases. Methods: Retrospective analysis of all patients visiting Nephrolo...
Same Heart and Different Sleep? A Brief Review of the Association between Sleep Apnea Syndrome and Heart Failure Based on Two Clinical Cases
The research in the field of sleep medicine has increased during the whole twentieth century, principally for the involvement of sleep-related disordered breathing (SDB) in cardiovascular disease. If sleep encompasses ab...
Cholesterol Lowering Effect of Cnidoscolous aconitifolius Leave Extracts in Egg Yolk Induced Hypercholesterolemia in Rabbit
Study Background: Cnidoscolous aconitifolius leaf (Chaya; Efo Iyana ipaja in Yoruba language) is a common vegetable plant served as sauce and has many traditional health benefit claims such as treatment of alcoholism, in...
Investigating of Mothers' Behavior Based on the Health Belief Model about Using Iron Supplementation in 6 to 24- Month Old Children in Shahrekord City, Iran
Background: Anemiais one of the most important problems in children's public health. Iron Deficiency Anemia is the most common type of anemia among this group. This study was conducted to determine mothers' behavior base...
Knowledge, Attitude and Practice of Family Planning among Women in a Rural Community in Southern Nigeria
Aims: This study was carried out to determine the knowledge, attitude and practice (KAP) of family planning (FP) among women of child bearing age in a community in south-south Nigeria. Methodology: This was a cross-secti...