MicroRNAs in Oncology
Journal Title: Global Journal of Biotechnology and Biomaterial Science - Year 2015, Vol 1, Issue 1
Abstract
MicroRNAs (miRNAs) are a family of short non-coding RNA molecules which contain about 18-24 nucleotides. miRNAs play significant regulatory roles in biological processes (cell proliferation, differentiation, survival and motility). miRNAs are essential regulators of coding genes at the post-transcriptional level. The biogenesis of miRNAs is composed of complex processes, and human genome contains approximately two thousand miRNAs (http://www.mirbase.org) [11. Tutar L, Tutar E, Tutar Y (2014) MicroRNAs and cancer; an overview. Curr Pharm Biotechnol 15: 430-437.,22. Calin GA, Croce CM (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 11: 857-866.]. Expression patterns of miRNAs have been found to have links with pathogenesis of many diseases including neurodegenerative diseases, diabetes, cardiovascular diseases, and particularly cancer.
Authors and Affiliations
Tutar Yusuf
Keywords
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- EP ID EP555761
- DOI 10.17352/gjbbs.000003
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