Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Tryptamine-Azole-Fluoroquinolone Conjugates
Journal Title: Archive of Biomedical Science and Engineering - Year 2018, Vol 4, Issue 1
Abstract
Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good–moderate antibacterial activity.
Authors and Affiliations
Cebeci Yıldız Uygun, Özdemir Serap Basoglu, Demirbas Ahmet, Karaoglu Sengül Alpay
Keywords
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- EP ID EP545642
- DOI 10.17352/abse.000009
- Views 62
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