MIDAZOLAM SYRUP AS A PREMEDICATION IN PAEDIATRIC PATIENTS- A RANDOMISED, DOUBLEBLIND, PARALLEL GROUP, PLACEBO-CONTROLLED STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 28
Abstract
BACKGROUND Premedication is expedient in reducing the psychological trauma from recalling the unpleasant pre-anaesthetic phases; hence, inducing a trouble-free anaesthesia. Aim- This study was done to evaluate commercially available midazolam syrup 0.25 mg/kg as a premedication in children with regard to sedation, anxiolysis and parental separation score. MATERIALS AND METHODS After IRB approval and written informed consent from parents, this study was conducted in 100 children (ASA I and II), aged 1 to 6 years who were scheduled for various elective and emergency surgeries. Patients were randomly divided into two groups (n= 50 each). Group A was control and Group B received midazolam syrup 0.25 mg/kg 45 minutes before surgery. RESULTS The acceptance of drug was very good. All children in Group A (without premedication) were extremely anxious and crying or thrashing, while in Group B 98% patients were calm and sleepy and separated happily from parents after 45 minutes. Midazolam did not impact the overall recovery time in children. None of the patients in either group developed any complication. CONCLUSION A dose of 0.25 mg/kg of commercially available midazolam syrup offers effective sedation and better emotional control facilitating better separation from parents.
Authors and Affiliations
Jaldeep BP, Shilpa M. D, Deepshikha CT
Keywords
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- EP ID EP537912
- DOI 10.14260/jemds/2018/724
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