Mitogen-activated protein kinases in atherosclerosis
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Intracellular signalling cascades, in which MAPK (mitogen-activated protein kinases) intermediate, are responsible for a biological response of a cell to an external stimulus. MAP kinases, which include ERK1/2 (extracellular signalling-regulated kinase), JNK (c-Jun N-terminal kinase) and p 38 MAPK, regulate the activity of many proteins, enzymes and transcription factors and thus have a wide spectrum of biological effects. Many basic scientific studies have defined numerous details of their pathway organization and activation. There are also more and more studies suggesting that individual MAP kinases probably play an important role in the pathogenesis of atherosclerosis. They may mediate inflammatory processes, endothelial cell activation, monocyte/macrophage recruitment and activation, smooth muscle cell proliferation and T-lymphocyte differentiation, all of which represent crucial mechanisms involved in pathogenesis of atherosclerosis. The specific inhibition of an activity of the respective MAP kinases may prove a new therapeutic approach to attenuate atherosclerotic plaque formation in the future. In this paper, we review the current state of knowledge concerning MAP kinase-dependent cellular and molecular mechanisms underlying atherosclerosis.
Authors and Affiliations
Dorota Bryk, Wioletta Olejarz, Danuta Zapolska-Downar
Keywords
Related Articles
- EP ID EP67256
- DOI -
- Views 145
- Downloads 0
Mechanisms of angiogenesis in neoplasia
Mechanism of forming new capillary from basal vessels, named angiogenesis, exist under both physiological and pathological conditions. Initiation of this process requires imbalance between proangiogenic and antiangiogeni...
Physical activity in the prevention and treatment of diseases of affluence – the key role of AMP-activated protein kinase (AMPK)
In developed countries, we can observe an increasing number of people with obesity, type 2 diabetes, dyslipidemia, hypertension and arteriosclerosis. The main reason for this phenomenon is the abnormal energy balance due...
The influence of TSA and VPA on the in vitro differentiation of bone marrow mesenchymal stem cells into neuronal lineage cells: Gene expression studies
Introduction: Epigenetic mechanisms regulate the transcription of genes, which can affect the differentiation of MSCs. The aim of the current work is to determine how the histone deacetylase inhibitors TSA and VPA affect...
Budowa i funkcja C1q składowej dopełniacza oraz jej znaczenie w rozwoju chorób o podłożu autoimmunologicznym
Układ dopełniacza należy do głównych mechanizmów efektorowych układu odpornościowego. Istnieją trzy drogi aktywacji: klasyczna, alternatywna i lektynowa, w które zaangażowanych jest ponad 30 białek surowicy. C1q jest pie...
The influence of melatonin and agomelatine on urodynamic parameters in experimental overactive bladder model – preliminary results
Introduction: Overactive bladder (OAB) is a common disease entity with complex pathogenesis that involves neurogenic, myogenic and abnormal paracrine urothelial activity mechanisms. Our objective was to estimate bladder...