MMP-9, MMP-2 Profile in Different Mice Tissues and LPS Induced MMP-9 and MMP-2 Expression in RAW 264.7 Cells, Down Regulated by Emodin Treatment
Journal Title: International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS) - Year 2014, Vol 1, Issue 9
Abstract
Emodin, an anthraquinones component of Rheum palmatun, has been used for anti-inflammatory purposes. However, its underlying molecular effect(s) on target cells remain to be well clarified. our current study was aimed at investigating the regulatory effect of Emodin on lipopolysaccharide induced inflammatory responses in RAW 264.7 macrophages by gelatin zymography . It was found that treatment of LPS(5µg/ml) for 18 h elevates the expression of MMP-9 and MMP-2 proteins in RAW 264.7 cells. It was also found that co-treatment of RAW 264.7 with drug Emodin(6µg/ml) and LPS(5µg/ml) for the period of 18 h reduces the expression level of MMP-9 and MMP-2 protein. Our data suggest that Emodin plays roles in regulating the digestion of Extracellular matrix by down-regulating the expression of MMP-9 and MMP-2 proteins.
Authors and Affiliations
Bilal Ahmad Lone
Keywords
Related Articles
- EP ID EP30740
- DOI -
- Views 326
- Downloads 0
Cross Border Crime and its Impact in Manipur,India
India shares its borders in the North-Eastern India with two countries i.e. Bangladesh and Myanmar. The crimes relating to cross border are frequently debated and highlighted as it poses serious threat to the economy an...
Development of Information Skills for Reading Periodicals - A study on Village Library
Everybody in the world is a reader. A Reader may be an individual or a group of persons who are the end users of any Library. A Reader refers and uses a large number of Books and Periodicals services to satisfy his/her...
A Comparative Perspective to the Mythological Concept of Escape from Time: An Archetypal Study
Time, the concept had ever been a matter of baffling obscurity to the humankind. Measuring of time may be an extension of man‟s quest to define life itself, an inborn crave to count the uncountable, and to define the in...
Real-Time Laser Sensor Data Acquisition and Three-Dimensional Image Reconstruction
A three-dimensional object can be measured and represented as a gray scale set of points through the use of LiDAR sensor with high spatial accuracy. The ability to quickly measure and represent tree canopy profile in 3D...
Theories and Tenets: An Impalpable Troll for the Policy Makers, Research Officers and Administrators?
Now we live in the age of professionalism, and the public office in any nation is some reservoir of intelligent competition in their specific field. They are the leaders and paragon of community as a loyal and professi...