Modern approaches to the treatment of herpetic infection in children
Journal Title: Актуальна інфектологія - Year 2019, Vol 7, Issue 3
Abstract
It is currently known 8 pathogenic herpesviruses: two types of herpes simplex virus (HSV-1, HSV-2), varicella zoster virus, Epstein-Barr virus, cytomegalovirus, HHV-6, HHV-7, and HHV-8. Herpes simplex virus type 1 and type 2 are members of the Herpesviridae family and are characterized by their ability to establish latency after primary infection and subsequently reactivate. After lytic infection on the surface of peripheral mucosa, HSV can enter sensory neurons and establish latent infection during which viral replication ceases. Moreover, latent virus can re-enter the replication cycle by reactivation and return to peripheral tissues to start recurrent infection. Drugs used today with anti-herpesvirus activity include acyclovir, cidofovir, famciclovir, foscarnet, ganciclovir, idoxuridine, penciclovir, trifluridine, valacyclovir, valganciclovir, and vidarabine. Inosine pranobex is another antiherpetic medication with direct antiviral and immunomodulatory activity. Inosine pranobex can improve the clinical course of the recurrent herpetic infection and accelerate the normalization of immunological parameters.
Authors and Affiliations
S. O. Kramarov, V. V. Yevtushenko
Keywords
Related Articles
- EP ID EP605922
- DOI 10.22141/2312-413x.7.3.2019.170993
- Views 78
- Downloads 0
Rare case of chiasm glioma in woman with hypogonadotropic hypogonadism and obesity
Chiasm glioma is a rare disease characterized by a decrease in the visual field. The aim of research was to describe a clinical case of chiasm glioma with concomitant hypogonadism and obesity. Reproductive function in 25...
Modern clinical and laboratory features of influenza in adults
We examined and treated 472 patients with influenza, 72 of them had radiologically confirmed pneumonia, and 69 were hospitalized in the intensive care unit of Kyiv Municipal Clinical Hospital N 4. We analyzed clinical an...
Clinical and epidemiological features of the course of rotavirus infection and the justification of its prevention in children
It was found that rotavirus infection occupies a large part among infectious gastroenteritis in children, with an increasing the incidences in winter and spring. We have studied the main clinical and diagnostic character...
Improving Treatment of Giardiasis
Giardiasis is one of the most common parasitic diseases in both children and adults, and is revealed in all countries of the world. Despite the wide range of etiotropic drugs, there remains a need to improve the treatmen...
The signs of epidemiological activation in Ukraine in the recent period
The article analyzes the tetanus morbidity in Ukraine for the period 2010–2016 and in other European countries for the period 2010–2015. The activated tetanus epidemic process among children was found in Ukraine unlike o...