Modern aspects of using nanocomposites for improvement of drugs (review)
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2018, Vol 32, Issue
Abstract
Introduction. The review article presents modern trends in the biotechnology of nanoparticles and nanocomposites in the development and improvement of medicinal and veterinary products. A special place among carriers able to delivery of medicines is occupied with inorganic nanoparticles. Using nanoparticles you able to optimize efficiency therefore minimize side effects. The goal of the review of scientific papers on the above-mentioned topics is the synthesis of modern research on the application of nanoparticles in nanotechnologies and the creation of nanocomposites for the improvement of medicinal products used in humane and veterinary medicine. Materials and methods. We used literary sources of electronic and printed publications on aspects of nanocomposites for the improvement of medicinal products, their transport in a living organism and prolongation of the action. Results of research and discussion. It was established that in animal husbandry, nanotechnology is used to introduce vaccines and medicines into the animals organism. Due to the ability of metal nanoparticles to surface coating with certain chemicals or biomolecules, in order to provide certain properties to nanoparticles, they can be conjugated to specific ligands of different structures. Certain success in the development of effective nanocomposite photosensitizers based on gold has been achieved through the rational design of the composite, which takes into account all the important characteristics of its components: gold nanoparticles, photosensitizers and auxiliary molecules (linkers, stabilizers), and the way they are combined. Preparations with silver nanoparticles showed antiviral and immunomodulating activity, synergistic enhancement of efficacy in the complex of silver with sulfonamides and other preparations. It has been established that bioavailability improves with the use of nanocomposites and controlled release of preparations becomes possible. Conclusions and prospects for further research. The toxicological aspect of the use of new preparations with nanoparticles is insufficiently studied. At the current stage, one of the priority areas is the development of interferon nanocomposites that can reduce the negative impact on human and animal organisms when interferon therapy applied.
Authors and Affiliations
Vitaliy Sinitsyn, Anna Zaviriuha, Y. N. Yenenko, K. V. Iavorska
Keywords
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- EP ID EP406254
- DOI 10.31073/vet_biotech32(2)-60
- Views 118
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