MODIFICATION OF RELEASE RATE OF SALICYLIC ACID FROM CHITOSAN MEMBRANE
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2012, Vol 0, Issue
Abstract
Due to continued interest in biodegradable polymers, chitosan is one of the most commonly used polymers in the field of control release of active substances. Currently as carriers of drugs, among tablets, or micro spheres transdermal systems, called films, are used. The presented results apply to study a drug release in buffer of pH = 7.2 from chitosan film. To study the kinetics of controlled release salicylic acid was used as a model substance. Obtained films were cross-linked in TPP solution and were also modified by applying outsider layer to slow down the release process. Received transdermal systems were tested with swelling kinetics and the release kinetics of salicylic acid. The obtained systems were tested in relation to different temperature of cross-linking solution of chitosan, different thickness of studied matrices, the influence of outside layer and varying initial amount of salicylic acid.
Authors and Affiliations
Maria Mucha, Iwona Michalak
MODIFICATION OF RELEASE RATE OF SALICYLIC ACID FROM CHITOSAN MEMBRANE
Due to continued interest in biodegradable polymers, chitosan is one of the most commonly used polymers in the field of control release of active substances. Currently as carriers of drugs, among tablets, or micro sphere...
INFLUENCE OF IMIDASOLIUM RING SUBSTITUTION ON CHITIN DISSOLUTION IN IONIC LIQUIDS
Presented paper discuss the influence of substitution of imidasolium ring on the solubility and structure of chitin. The 1-butyl-3-methyl imidazolium chloride (BMIM)(Cl) and the 1-butyl-2,3- dimethyl imidazolium chloride...
CELL BINDING AND PENETRATION OF QUATERNIZED CHITOSAN DERIVATIVES
Chitosan (Ch) is an attractive biopolymer with multiple reactive groups. However it is poorly soluble at neutral pH. Quaternization improves its solubility and permits the development of various positively charged drug d...
Use of Chitosan Film Coatings in the Storage of Carrots (Daucus carota)
Chitosan film applied to coat carrot slices affected metabolic changes that increased the content of total phenolic acids and flavonoids. Chitosan coating of carrot slices delayed the overripening process and, consequent...
THE INHIBITION OF HUMAN PLATELET AGGREGATION BY A LOW-MOLECULAR WEIGHT CHITOSAN
Chitosan derivatives were obtained by chemical (MW of 6 kDa, DD 99% - Ch6/99; MW13 kDa, DD 98% - Ch13/98) and enzymatic (MW of 5 kDa, DD 85% - Ch5/85; MW of 10 kDa, DD 85% - Ch10/85) depolymeri-sation of chitosan with a...