Modulatory effect of NONI-Herbal formulation against ethylene glycol induced nephrolithiasis in albino rats.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 3
Abstract
The effect of NONI-herbal formulation against ethylene glycol induced nephrolithiasis in albino wistar rats is summarized in this study. Lithiasis was induced in rats by administering 0.75% ethylene glycol in drinking water for 28 days and was manifested by high urinary calcium, phosphate, oxalate, and low urinary magnesium contents. Simultaneous administration of 1ml (1 in 10) NONI formulation orally for 28 days along with ethylene glycol (0.75% v/v) reduced urinary calcium, phosphate, oxalate and elevated urinary magnesium level. It also increased urinary volume thereby reducing the tendency for crystallization. The histopathological studies confirmed the induction as degenerated glomeruli, necrotic tubule and inflammatory cells was observed in section of kidney from animals treated with ethylene glycol.This was reduced; however after treatment with NONI formulation. These observations enable to conclude that NONI is effective against ethylene glycol induced nephrolithiasis.
Authors and Affiliations
Verma N. K. , Patel S. S. , Saleem T. S. M, Christina A. J. M, Chidambaranathan N.
Keywords
Related Articles
- EP ID EP129121
- DOI -
- Views 114
- Downloads 0
Development and Physiochemical, In-Vitro Evaluation of Antihypertensive Transdermal
Transdermal patches of Losartan with hydrophilic and hydrophobic polymers containing the drug reservoir were prepared by solvent evaporation method. In this experiment, the membranes of ethylcellose and eudragit RS...
Improvement of Solubility and Dissolution of Indomethacin by Liquisolid and Compaction Granulation Technique
The purpose of this study was to develop novel techniques to enhance the dissolution rate of poorly watersoluble drugs substance Indomethacin (IM).The granules of IM were prepared by nonaqueous liquisolid andc...
Pharmacological studies of anticancer, anti inflammatory activities of Murraya koenigii (Linn) Spreng in experimental animals
The aim of the present study is to evaluate the effect of column (SU I, SU II, SU III) extracts of the plant Murraya koenigi against in vitro (short term incubation method, SU I, SU II, SU III) and in vivo (Da...
Comparative study of prescribing behaviors of government doctors of teaching hospital and private practitioners in Jhalawar City (Rajasthan)
To compare various aspects of prescribing behaviors of government doctors of teaching hospital and private practitioners. Prescription audit was conducted for a period of 2 months for out patient departments (OPDs)...
Stability-indicating High Performance Thin Layer Chromatographic Determination of Clozapine in Tablet Dosage Form
A simple, selective, precise and stability-indicating high-performance thin-layer chromatographic method of analysis of Clozapine in pharmaceutical dosage form was developed and validated. The method employed TLC alumini...