Development and Physiochemical, In-Vitro Evaluation of Antihypertensive Transdermal

Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 3

Abstract

 Transdermal patches of Losartan with hydrophilic and hydrophobic polymers containing the drug reservoir were prepared by solvent evaporation method. In this experiment, the membranes of ethylcellose and eudragit RS 100 were used to achieve controlled release of the drug. The prepared patches showed satisfactory physiochemical characteristics of weight variation, thickness, folding endurances, moisture absorption and drug content were uniform in all patches. In-vitro permeation studies were done by using Franz diffusion cell having cellophane membrane. The effect of non- ionic surfactant like tween 80 and span 80 on drug permeation were studied. Based on the kinetic studies, the patch containing both HPMC and Eudragit RS100 showed satisfactory drug release patterns.

Authors and Affiliations

V. Vijaya , M. H. Sumanth , L. Suman , T. Vinay , D. Srinivasrao , K. Jayaraj Kumar

Keywords

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  • EP ID EP107947
  • DOI -
  • Views 120
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How To Cite

V. Vijaya, M. H. Sumanth, L. Suman, T. Vinay, D. Srinivasrao, K. Jayaraj Kumar (2010). Development and Physiochemical, In-Vitro Evaluation of Antihypertensive Transdermal. Journal of Pharmaceutical Sciences and Research, 2(3), 171-177. https://europub.co.uk/articles/-A-107947