Molecular Imaging of Membrane Transporters’ Activity in Cancer: a Picture is Worth a Thousand Tubes
Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 4
Abstract
Molecular imaging allows the non-invasive assessment of membrane transporter expression and function in living subjects. Such technologies have the potential to become diagnostic and prognostic tools, allowing detection, localization, and prediction of response of tumors and their metastases to therapy. Beyond tumors, imaging can also help understand the role of transporters in adverse drug effects and drug clearance. Here, we review molecular imaging technologies that monitor transporter-mediated processes. We emphasize emerging probe substrates and potential clinical applications of imaging the function of membrane transporters in cancer.
Authors and Affiliations
Aniv Mann, Inessa Semenenko, Michal Meir, Sara Eyal
Keywords
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- EP ID EP680965
- DOI 10.1208/s12248-015-9752-6
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