Molecular Mechanics and 3D structure validation studies on PCO and Hypothyroidism (SHBG) gene using Insilico protocols
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2016, Vol 6, Issue 2
Abstract
It has been estimated by the World Health Organization that PCOs affects 116 million women worldwide as of 2010 (3.4% of women). In the United States hyperthyroidism affects about 1.2% of the population. About half of these cases have obvious symptoms while the other half do not. The disease is more common in those over the age of 60 years. These two disorders are clinically associated. The aim of our research is to model the SHBG protein and to validate the 3D structure using insilico software and tools. Identification of the potential protein target is a basic step in structure-based drug designing. The modelled SHBG protein is involved in both PCOs and hypothyroidism. In our future studies, we shall use this modelled protein to introduce the novel drug candidate using molecular drug docking studies.
Authors and Affiliations
D. Parimala nandhini , D. Leelavathi
Keywords
Related Articles
- EP ID EP139008
- DOI -
- Views 78
- Downloads 0
[u][/u]Analysis on creatinine reducing herbals renal as protective agents in rat
Tribulus terrestris (Nerunji mullu), Butea monosperma (Parasa pattai) and Chicorium intybus (Kasini keerai) are the traditional herbal medicines used in Siddha and Ayurvedic system. They are analyzed for their creatini...
A Comprehensive Review on Infusion Solution
In olden days the drug product can be injected in to the infusion bottle and then the mixed drug solution can be injects to the patient. In this process may be there is a chance for the contamination of the drug product....
Identification of insilico drugs and drug docking studies on hypothyroidism and inferility disorders in human
Hypothyroidism is a common endocrine disorder in which the thyroid gland does not produce sufficient thyroid hormone. It can cause a number of symptoms, such as tiredness, poor ability to tolerate cold, and weight gain....
RP-HPLC method development and validation of valizodone in pure and tablet dosage form
A simple, precise, rapid, accurate and economic reverse phase high performance liquid chromatographic method has been developed for the estimation ofValizodone in tablet dosage form. The separation was achieved by using...
Area study based on statistical analysis for diabetic retinopathy
Diabetic eye disease refers to a group of eye problems that people with diabetes may face as a complication of diabetes. All can cause severe vision loss or even blindness. It is caused by changes in the blood vessels of...