Molecular virological mechanism of the mother-to-child transmission of hepatitis B virus
Journal Title: Journal of Clinical Hepatology - Year 2024, Vol 40, Issue 11
Abstract
Chronic hepatitis B virus （HBV） infection is a major global public health threat. In areas with moderate to high prevalence of HBV， mother-to-child transmission （MTCT） remains the main source of chronic HBV infection. With the application of combined immunization of hepatitis B vaccine and hepatitis B immunoglobulin in neonates， there has been a significant reduction in the incidence rate of HBV MTCT， but there is still a high risk of HBV MTCT in infants born to mothers with positive HBeAg and high viral loads. Although antiviral therapy for pregnant women with high HBV viral loads in late pregnancy can further reduce the risk of HBV MTCT， it is still difficult to completely block HBV MTCT. A deep understanding of the molecular virological mechanisms of HBV MTCT can provide clear ideas for blocking HBV MTCT， which is of great significance for the prevention and management of HBV MTCT.
Authors and Affiliations
Yarong SONG, Jie WANG, Jie LI
Keywords
Related Articles
- EP ID EP753513
- DOI 10.12449/JCH241107
- Views 24
- Downloads 1
Value of Δtotal bilirubin-alpha-fetoprotein scoring model in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure
[Objective] To investigate the association of the dynamic changes of serum total bilirubin （ΔTBil） and alpha-fetoprotein （AFP） with the short-term prognosis of patients with hepatitis B virus-associated acute-on-chro...
Research advances in the pathogenesis of metabolic associated fatty liver disease
Metabolic associated fatty liver disease （MAFLD） is currently the most common liver disease around the world. MAFLD may easily progress to the adverse outcomes such as hepatitis， liver fibrosis， and liver cirrhosis，...
Several issues in the surgical treatment of intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma （ICC） ranks second among malignant liver tumors and has high malignancy and poor prognosis. Currently， surgical treatment remains the only potentially curative therapy for ICC， but wit...
Efficacy and safety of camrelizumab monoclonal antibody combined with molecular-targeted therapy in elderly patients with advanced hepatocellular carcinoma
[Objective] To investigate the efficacy and safety of camrelizumab monoclonal antibody combined with molecular-targeted therapy in elderly patients with unresectable or advanced hepatocellular carcinoma （HCC）. [Methods...
New advances in antiviral therapy during pregnancy to block mother-to-child transmission of hepatitis B virus
Mother-to-child transmission of hepatitis B virus （HBV） is one of the primary causes of the high disease burden of chronic hepatitis B in China， and blocking this route of transmission has an important strategic signi...