Monitoring Crohn’s disease activity: clinical, endoscopic and histological indices
Journal Title: Postępy Nauk Medycznych - Year 2014, Vol 27, Issue 3
Abstract
Crohn’s disease (CD) together with ulcerative colitis (UC) belong to chronic gastrointestinal condition called inflammatory bowel disease (IBD). The clinical course of both disorders is similar and is characterized by exacerbations and spontaneous or drug-induced remissions but their histopathological features are different. Moreover, the various clinical patterns are reflected in the microscopic features observed in biopsies obtained during endoscopy, which is used for monitoring of disease activity. However, endoscopic mucosal biopsies do not show all the characteristic features of CD. In the last years, many disease-specific instruments, especially complex numeric activity indices to measure activity have been created. Therefore, the review of biopsies, in combination with clinical, laboratory, radiographic and endoscopic observations, is needed for both diagnosis and monitoring of IBD, and for the differentiation CD and UC from other conditions. The aim of this article is to make a revision of available clinical, endoscopic and histopathological scales used in common practice for diagnosis and monitoring of CD.
Authors and Affiliations
Edyta Szymańska, Jarosław Kierkuś
Keywords
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