Moringa oleifera Enriched Diet Ammeliorates the Toxic Effects of Palm Wine and Local Gin (Ogogoro) on Some Biochemical Parameters in Albino Rats
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 21, Issue 8
Abstract
The effect of Moringa oleifera enriched diet on the toxic effects of palm wine and local gin on liver enzymes, lipid profile and electrolytes in albino rats was determined in this research. Methodology: Thirty female albino wistar rats, aged 8 to10 weeks, weighing between 170 and 200 g were used for the study. They were divided into six groups of five rats each. Group 1 served as the control group (given normal diet), group 2 rats were given Moringa oleifera enriched diet only, group 3 rats were given 10 ml/kg bwt of palm wine only and fed a normal diet, group 4 rats were given 0.03 ml/kg bwt of local gin and fed a normal diet, group 5 rats were given 10 ml/kg bwt palm wine with Moringa oleifera enriched diet and group 6 rats were given 0.03 ml/kg bwt of local gin with Moringa oleifera enriched diet. Palm wine and local gin were administered to the rats daily using an oral cannula for 30 days. On the 31st day, the rats were sacrificed and blood was collected through cardiac puncture for the determination of some liver enzymes, lipid profile and electrolytes. Results: The results of this study showed that Moringa oleifera enriched diet significantly decreased (p<0.05) the activities of alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase, and significantly increased (p<0.05) the levels of total protein and albumin when compared with the control rats. Also, Moringa oleifera enriched diet caused significant decrease (p<0.05) in the levels of total cholesterol, triglycerides, low density lipoprotein-cholesterol and very low density lipoprotein-cholesterol; with significant increase (p<0.05) in high density lipoprotein-cholesterol when compared to control rats. Treatment with the extract significantly lowered (p<0.05) the levels of urea and creatinine in Groups 3, 4 and 5 rats compared with Group 2 rats. Furthermore, the significant reduction (p<0.05) in the levels of sodium, potassium, chloride and bicarbonate was reversed by, treatment with M. oleifera enriched diet. Conclusion: The results suggest that the Moringa oleifera enriched diet could possibly ameliorates the toxic effects of palm wine and local gin on some biochemical parameters in rats.
Authors and Affiliations
Okwari Obem, Kolawole Tolunigba Abisola, Oluwatayo Beatrice Olatundun
Keywords
Related Articles
- EP ID EP311763
- DOI 10.9734/BJMMR/2017/29479
- Views 56
- Downloads 0
Tolerability of The Copper- T Intrauterine Device by Acceptors at Jos University Teaching Hospital, Jos, North-Central Nigeria
Background: The Copper-T (Cu-T) Intrauterine device (IUD) is one of the oldest and most reliable forms of contraception. Its widespread use has been limited by side effects, such as heavy menstrual flow and pain on inser...
The Role of Graduated Drivers' Licensing on Incidence and Severity of Road Traffic Injuries in Iran
Aims: This study investigated the role of graduated drivers licensing, implemented by the Traffic Police of Iran, on reducing the severity and incidence of road traffic injuries. Study Design: It was an evaluation of the...
Is the Naming of Herpes Simplex Gladiatorum Correct?
Ηerpes Gladiatorum (HG) outbreaks should be regarded as serious long term infections that can have negative consequences on the health of individual athletes and the athletic community as a whole. Purpose: The main goal...
Prevalence of Hepatitis B and Hepatitis C Infections in HIV Infected Patients Attending a Tertiary Care Hospital in North-East India
Aims: To study the co infection of Hepatitis B (HBV) and/or Hepatitis C virus (HCV) in Human Immunodeficiency Virus (HIV) infected patients attending tertiary care teaching hospital in North East India. Study Design: Th...
Risk Factors Associated with Wound Infection Following Caesarean Section - A Hospital Based Study
Aim: To find out the risk factors associated with wound infection following caesarean section. Design: Prospective cohort study. Place and Duration of Study: This study was carried out in the Department of Obstetrics and...