Morphofunctional changes in internal organs of rats upon chronic exposure of micro and nanoparticles of inorganic lead compounds on their intact skin
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 79, Issue 3
Abstract
Today there is a rapid development of nanomaterials and nanotechnology. Metal nanoparticles (NPs) are widely implemented in various spheres of economic activity, creating a potential risk for workers’ health and the environment. Especial attention deserves nanoparticles of lead since the possibility of their formation in the production process is quite large, and the nature of the effect on the body to these almost not studied. The aim of the study. Morpho-functional assessment of internal organs of rats in application micro and nano of inorganic compounds of lead to intact skin. Materials and Methods. A chronic experiment was conducted on 24 Wistar male rats, divided into 4 groups. 1 ml of colloids was applied to rats of groups II, III and IV on the previously sheared back skin of 2 cm area, daily (5 days per week) for 3 months for 4 hours. PbS NPs were of size of 12,5 nm and 100 nm, and aqueous solution of lead acetate, group I included control intact rats. A morphological study of internal organs (myocardium, liver and kidney) was carried out, using general histological methods. Results of the Study. It is established that a prolonged exposure to undamaged rats skin of 12,5 nm and 100 nm PbS nanoparticles, unlike aqueous trihydrate lead acetate solution, the average particle size of which is 700 nm, is accompanied by resorption of nanoparticles through the intact skin, which ensures their absorption into the body and intake to target organs, where nanoparticles can exhibit toxic effects. Conclusions. PbS nanoparticles of different sizes with long-term effects on the intact skin in contrast to the particles of the micrometer range cause a wide range of morphological changes, characterized by their cardiovasotoxic, hepatotoxic and nephrotoxic effects.
Authors and Affiliations
S. P. Luhovsky, M. M. Didenko, N. A. Melnik
Keywords
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