Morphological Features in the Parathyroid Gland in Rats Caused by Simulated Influence of Heavy Metal Salts
Journal Title: Український журнал медицини, біології та спорту - Year 2017, Vol 8, Issue 6
Abstract
The heavy metal salts are marked by high toxicity and the ability to accumulate in the environment and organism, which leads to disorders of the organism functioning and the emergence of endemic diseases. The functional value of the parathyroid glands is based on the regulation of calcium metabolism in the body. This work is devoted to parathyroid gland morphological features studying of the white laboratory rats for the use of heavy metal salts. The study was conducted on 12 white laboratory rats that were divided into 2 groups: control (I), experimental with consumption combinations of heavy metals (II). The experimental laboratory animals were kept in accordance with all adapted regulations. After the experiment, the histologist specimens were stained with hematoxylin and eosin. The specimens were analyzed using a light microscope Nikon E 100. The study of control series of rats (I) showed oval compact the parathyroid gland with the normal structuring. It is separated by a connective tissue capsule from the thyroid gland. The connective tissue capsule inside the gland leaves the thin layers of the connective tissue that forms the stroma of the organ. Parenchyma is represented by the small cell cages, which are located mainly along the capillaries. Under the conditions of water consumption with heavy metal salts, according to the experiment, reactive changes in the parenchyma of the parathyroid gland were observed in the experimental group of rats (II). A vast connective tissue overgrowth is observed in the organ framework, hypostasis. Tincture properties are changed in parathyroid cells. The nuclei in cells are different in size and shape. Vaccination of the cytoplasm is observed in comparison with the control group. Thus, the combination using of heavy metal salts caused a negative change in the morphological, histological structure of the parathyroid gland, which on the other hand affected the functional state of the organ and the whole organism.
Authors and Affiliations
A. Romaniuk, O. Tymakova
Keywords
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