Morphology of the articular cartilage of the knee joint in rats with extraarticular femoral bone deformity (Морфологія суглобового хряща колінного суглоба щурів за умов позасуглобової деформації стегнової кістки)
Journal Title: Orthopaedics, Traumatology and Prosthetics - Year 2017, Vol 606, Issue 1
Abstract
Objective: to assess the structural and functional state of the rat knee after modeling posttraumatic extraarticular deformation of the femur. Methods: experiment was performed in 39 white mature (6 months old) male rats. To model the deformation of varus (test group, 15 rats) after transverse osteotomy of the femur, a bent angled rod was introduced into the medullary canal, the control animal (15) was straight. The comparison group was intact rats (9) of the corresponding age and sex. After 1, 3 and 6 months. After the operation, histological examination was performed. Results: In 1 month after modeling the deformation in the articular cartilage of the knee joint, destructive changes of 1–2 degree according to OARSI were noted. In contralateral extremity, AC had a structure characteristic of the age norm. After 3 months a decrease in the width of articular cartilage (in comparison with intact group by 1.21 times, p < 0.01), loss of glycosaminoglycans, a violation of the structure and ordering of collagen fibers, accumulation of type I collagen was established. After 6 months the most pronounced disorders were found in the cerebral cortex on the medial condyle of the deformed femur — a 1.63 fold decrease in its width compared with the intact group (p < 0.001), in places the replacement with fibrous cartilage. Conclusions: in animals with simulated extraarticular deformation of the femur in the knee joint of the injured limb after 1 month revealed destructive changes that progressed with time. After 1 month the maximum manifestation of disorders was noted in the area of the femur surface under the patella, and after 3 and 6 months he medial condyle. In the articular cartilage of the knee joint of the contralateral limb, destructive changes were recorded 3 months after the reproduction of the deformation, but the severity of the manifestations was less.
Authors and Affiliations
Konstantin Romanenko, Nataliya Ashukina, Inna Batura, Dmytro Prozorovsky
Keywords
Related Articles
- EP ID EP336551
- DOI 10.15674/0030-59872017163-71
- Views 186
- Downloads 0
BIOMECHANICAL RATIONALE OF ACETABULAR WALL AUGMENTATION METHOD FOR JOINT REPLACEMENT IN CONDITION OF OSTEOPOROSIS
Osteoporosis worsens the qualitative and quantitative characteristics of bone, which is a hostile environment for the stable long-fixation of acetabular component in hip joint endoprosthesis. Despite the large number of...
Morphological peculiarities of bone healing in the place of experimental cortical defect of long bone of rats in the conditions of naturalhydroxyapatite implantation
The goal: to investigate bone-healing process after implantation of osteoplastic material Cerabone® in compact bone defect. Methods: experiment was performed on 24 white rats (male). Hole-like defect (2.5 mm diameter) w...
THE EFFECTIVENESS OF THE DIFFERENT SCHEMES OF COMPLEX CONSERVATIVE TREATMENT OF ANIMALS WITH INDUCED KNEE ARTHRITIS
The effectiveness of conservative treatment in patients with knee joint arthritis can be enhanced through the use of the linked pharmacological and physical factors. The possibility of comprehensive use of low-intensity...
Functional spine analysis at surgical treatment of burst fractures of thoracic and lumbar spine [Аналіз функціонального стану хребта за умов хірургічного лікування вибухових переломів грудного та поперекового відділів]
Burst fracture — is traumatic injury under the influence of high-energy axial compression which results multifragmentary vertebrae fracture with penetration of bone fragments into spine canal and paravertebral tissues. O...
Comparison of radiological and clinical assessments patellar resurfacing with retention for late stages of knee osteoarthritis performed total knee arthroplasty
Introduction: the purpose of this prospective study was to compare radiological and clinical outcomes after total knee arthroplasty (TKA) with or without patellar resurfacing in patients with grade IV osteoarthritis on p...