Mott Cells - at a Glance
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Mott cells are cells which have grape like intra cytoplasmic inclusions arranged in a globular manner. They are architecturally plasma cells. They were also named as Immunoglobulins and Russel bodies by researchers. The term Russel body is a Pathologists term. Russel has described the intracytoplasmic inclusions as cherry red inclusion bodies. Similar other intracytoplasmic inclusions that appear in plasma cells are called Dutcher bodies which now are considered as pseudo inclusions as per the WHO 2008 classification. There are several Pathologies which contain these Russel bodies, they are Multiple Myelomas, Leukemias, Chronic infections, gastric carcinoma and so on. Hence a range of Pathologies ranging from neoplasms to reactive lesions have demonstrated these cells. Many special stains like PAS, MGG can be used to observe and demonstrate these cells. Also a panel of IHC markers can be useful to study these cells using Immunohistochemistry techniques. If the balance between synthesis, degradation and secretion is lost, it results in the formation of mutant forms. Thus a thorough understanding of these cells is essential.
Authors and Affiliations
Manasa Ravath CJ, Noopur Kulkarni, Roshini Vinod
Keywords
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