Mucinous and Non-Mucinous Adenocarcinoma in Colorectal Cancer Patients
Journal Title: Iranian Journal of Blood and Cancer - Year 2016, Vol 8, Issue 3
Abstract
Background: The oncologic behavior of mucinous adenocarcinoma (MA) of colorectal differs from non-mucinous adenocarcinoma (NMA). MA is more advanced at diagnosis and has a poorer prognosis than NMA. We aimed to evaluate prognostic factors and survival rate in patients with MA compared with NMA in Western Iran. Methods: During 2008-2015 in a retrospective study, 83 patients with CRC referred to the Oncology Clinic in Kermanshah, Iran. Binary logistic regression analysis was used for the correlation between risk variables with the type of pathology. Results: The mean follow-up was 32 months (range, 12-72 months) and in this interval, there were 26 deaths and 3 patients were lost to follow-up and therefore, were omitted them from survival analysis. There was no significant correlation between NMA and MA with sex, degree of differentiation of tumor, tumor site, tumor size, KRAS mutation and lymph node metastasis, but a significant correlation was observed with age (P<0.05). Binary logistic regression analysis showed there was a significant correlation between age (P=0.01, odds ratio 11.93 and 95% CI 1.61-88.46) and type of pathology. The survival rate and mean survival were 54.3% and 23 months for NMA group, versus 80.6% and 25.4 months for MA group, respectively. Conclusion: The prevalence of NMA in CRC was more than MA. In this study, the MA patients had lower age and more risk of recurrence compared to NMA patients and unlike other studies, 5-year survival rate was significantly higher in NMA patients than that in MA patients.
Authors and Affiliations
Mehrdad Payandeh, Masoud Sadeghi, Edris Sadeghi
Keywords
Related Articles
- EP ID EP250808
- DOI -
- Views 102
- Downloads 0
Leukocytosis in Preterm Infants with Intraventricular Hemorrhage
Background:Intraventricular hemorrhage is the most common intracranial hemorrhage in premature infants. The objective of this study was to investigate the relationship between intraventricular hemorrhage and blood leukoc...
Clinical Significance of Positive Platelet Immunofluorescence Assay in Adult Immune Thrombocytopenia: a Cross Sectional Study
Background: Immune thrombocytopenia is a hematologic disorder characterized by low platelet count and variable bleeding manifestations due to immune-mediated platelet destruction and/or suppression of platelet production...
Neutropenia Following Intravenous Immunoglobulin Therapy in Pediatric Patients with Idiopathic Thrombocytopenic Purpura
Background: Children with idiopathic thrombocytopenic purpura who are treated with intravenous immunoglobulin therapy might experience a decline in their absolute neutrophil count. The aim of this study was to investigat...
Beta-Globin Gene Cluster Haplotypes in Iranian Sickle Cell Patients: Relation to Some Hematologic
Background: Sickle cell anemia is relatively common in Khuzestan province located in Southwest Iran. The characteristics of sickle cell disease in Iran are apparently different from other regions some of these characteri...
Studies of Human HbAA Erythrocyte Osmotic Fragility Index of Non-Malarious Blood in the Presence of Five Anti-malarial Drugs
Background: The capacity of human HbAA erythrocytes of non-malarious blood to withstand osmotic stress in the presence of five antimalarial drugs, Chloroquine phosphate, Quinine, FansidarTM, CoartemTM and HalfanTM was st...