Multi-Component Synthesis of Novel Diazoles: their Characterization and Biological Evaluation
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 1, Issue 2
Abstract
A new series of imidazoles were synthesized by multiple component system through condensation reaction of benzil, substituted aldehydes, substituted anilines and ammonium acetate. Glacial acetic acid was used as solvent. The bonding behavior and structure of the prepared compounds have been deduced from infra red spectroscopy, conduction method, and CHN analysis data. The synthesized imidazoles have been examined for in-vitro antibacterial properties. The results of these studies have shown that all compounds exhibited fair to major antibacterial activity against one or more bacterial strains.Multi-component reactions (MCRs) have been extensively used in organic synthesis and medicinal chemistry. These reactions show high synthetic efficiency and are further used for the preparation of complex compounds from simple reactants [1]. MCRs are also applied to the syntheses of tetra substituted imidazoles [2]. Tetra substituted imidazoles are very significant heterocyclic compounds in pharmaceutical and biochemical processes [3]. They are biologically active compounds having fungicidal [4], antiinflammatory [5], analgesic [6], antitumor [7] and antibacterial activities [8]. Substituted imidazoles are widely used as glucagon receptors [9], CB1 cannabinoid receptor antagonists [10] and modulators of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) agents [11]. It can also be employed as herbicides [12], fungicides and plant growth regulators [13]. Imidazoles as ionic liquids and imidazole related N- heterocyclic carbenes are extensively used as green solvents [14].
Authors and Affiliations
Shad HA, Hussain A, Shahzad K, Abeeha A, Khan ZI, Llyas M, Alam MM
Keywords
Related Articles
- EP ID EP576735
- DOI 10.32474/AOICS.2018.01.000107
- Views 78
- Downloads 0
On Efficiency of Application of Irrigation Systems With Low Intensity at Azerbaijan’s Slot Land
The study of the world experience and the results of long-term experiments on drip irrigation systems in various climatic and soil conditions shows that the creation of irrigation systems of this type is effective and ec...
Metals Phytotoxicity Assessment and Phyto Maximum Allowable Concentration
Metals are significant environmental pollutants, and their toxicity is a problem of increasing significance for ecological, evolutionary, nutritional and environmental reasons Nagajyoti [1]; Bieby Voijant Tangahu [2]; Ma...
Crystal and Molecular Docking Studies of 3-[Bis-(2- Hydroxy-4,4-Dimethyl-6-Oxo-Cyclohex-1-Enyl)-Methyl]Benzonitrile with Focal Adhesion Kinase Inhibitors
Cyclohexane is found naturally to some extent in petroleum but is prepared commercially by catalytic hydrogenation of benzene.It is widely used as a solvent and in making certain compounds used in the preparation of nylo...
Improved Enantioselective Enzymatic Synthesis of (S) - Pregabalin
Pregabalin is available in the market under the brand name of Lyrica among others. It is a drug of choice for the treatment of epilepsy, fibromyalgia, sweeping anxiety disorder and neuropathic pai...
Mercury Toxicity: Ecological Features of Organic Phase of Mercury in Biota- Part I
Mercury is extensively used in industry with top usage in electrolytic chlorine. As a result of this elemental consumption in industry, different forms of inorganic and organic mercury get into the environment in great p...