Multicenter clinical and immunological study on Addison’s disease in Poland
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 12
Abstract
Introduction. Primary adrenal insufficiency – Addison’s disease (AD) is a rare disease,developing mainly due to autoimmune processes. Autoimmunity against 21-hydroxylase,an enzyme participating in steroidogenesis, is the most frequent pathogenic factor in AD.Aim. Our study aimed at evaluating the incidence of 21-hydroxylase (21-OH) antibodiesand presence of other immunological disorders in patients with primary adrenal insufficiency.Material and methods. 212 patients (160 women) with hormonally documented Addison’sdisease, aged 20-84 years, observed for 1-52 years. Clinical examination, 21-hydroxylaseand thyroid autoantibodies investigations. The results obtained in 2012 were comparedwith the results of adrenal autoantibodies measured in 2000 (then of 62 patients, adrenalantibodies were detected in 39 persons and 30 of them were investigated again in 2012).Results. In 212 patients examined in 2012 antibodies to 21-OH were presentin 114 cases (54%). Among 30 patients examined in 2000, 27 cases showed 21-OH positivity,whereas twelve years later antibodies were detected in only 13 cases. Presence ofthyroid antibodies was the most frequent immunological finding, while hypothyroidismwas the most frequent autoimmune disease.Conclusions. 1. The incidence of positive results of 21-OH antibodies in 2012 = 54%appeared to be lower than in Scandinavian cohorts, probably due to long term observationin Poland. 2. A conversion from a positive immunological phenotype to a negative oneduring 12 years period of observation seems to confirm this suggestion.
Authors and Affiliations
Anna Kasperlik-Załuska, Lucyna Papierska, Wojciech Jeske, Renata Kapuścińska, Barbara Czarnocka
Keywords
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