Development and Advanced Validation of an Optimized Method for the Quantitation of Aβ42 in Human Cerebrospinal Fluid

The online version of this article (doi:10.1208/s12248-012-9360-7) contains supplementary material, which is available to authorized users.

On the Incorrect Statistical Calculations of the Kinetica Software Package in Imbalanced Designs

This regulatory note supports the previous findings that suggest that the software package Kinetica, up to version 5.0.10, provides incorrect results for the 90% confidence intervals for the ratio test/reference where th...

Editorial: A New Series of Commentaries Entitled “Landmark Publications in the Pharmaceutical Sciences: The Backstory”

Endocannabinoid signaling directs periimplantation events

An emerging concept in female reproduction is the role of endocannabinoids, a group of endogenously produced lipid mediators that bind to and activate cannabinoid receptors. Although adverse effects of cannabinoids in fe...

Current methodology to assess bioequivalence of levothyroxine sodium products is inadequate

Levothyroxine sodium is a drug with a narrow therapeutic index for which an individual patient must have his or her dose carefully titrated to achieve the necessary therapeutic effect. In addition, exogenous levothyroxin...