Multiple-Antibiotic Resistance in Salmonella enterica Serovars Isolated in Iran Harboring Class 1 Integrons
Journal Title: Microbiology Research Journal International - Year 2015, Vol 5, Issue 2
Abstract
Aims: This research was carried out to detect the content and distribution of class 1 integrons in multidrug resistant Salmonella isolates. Materials and Methods: Eighty four clinical isolates of Salmonella serovars were subjected to molecular detection of class 1 integrons following the antimicrobial susceptibility test using disk diffusion method and MIC determination. Results: Eleven isolates (13.1%) which were resistant to at least 4 groups of antimicrobial agents considered as MDR (multidrug resistant) Salmonella serovars. The intI1 gene and internal variable regions (IVRs) of class 1 integron were detected in 50 (59.5%) and 35 (70%) of Salmonella clinical isolates respectively. Analysis of the sequence data revealed four gene cassette arrays including the dhfr7 (0.8 kb), aadA1 (1kb), blaP1 (1.2 kb), dhfr1-aadA1 (1.6 kb) with eight IVR distribution patterns. Conclusion: Detection of class 1 integron carrying gene cassettes which confer resistance to different classes of antibiotics such as aminoglycosides, ß-lactams and trimethoprim confirms that integron-mediated antimicrobial gene cassettes are prevalent in Salmonella serovars isolated in Iran.
Authors and Affiliations
Bahareh Rajaei, Nahid Sepehri Rad, Farzad Badmasti, Mohamad Reza Razavi, Mohammad Reza Aghasadeghi, Raheleh Saboohi, Taraneh Rajaei, Arfa Moshiri, Seyed Davar Siadat
Keywords
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- EP ID EP354659
- DOI 10.9734/BMRJ/2015/9303
- Views 91
- Downloads 0
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