Myths and verities in protein folding theories Part II: From Kauzmann’s conjecture to the dominance of the hydrophobic effect
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2013, Vol 3, Issue 2
Abstract
   We start with Kauzmann’s conjecture regarding the factor which is most likely to determine the stability of the 3D structure of the proteins. We show first that Kauzmann’s model-process, on which the original conjecture was based is inadequate for the process of protein folding. The main reason for this is that protein folding involves the change in the conditional solvation of non-polar groups, not the solvation itself. The “condition†here is the presence of the protein backbone. Secondly, it is argued that various hydrophilic effects, both solvation and interactions are more likely to be dominant both in stabilizing the 3D-structure of proteins, as well as in determining the speed and the specificity of the folding process.
Authors and Affiliations
Arieh Ben Naim
Keywords
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- EP ID EP652547
- DOI 10.24297/jac.v3i2.933
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