NANOMATERIALS BASED ACETYLCHOLINESTERASE BIOSENSORS FOR ORGANOPHOSPHORUS COMPOUNDS DETECTION: REVIEW
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 2
Abstract
Due to intense pressure on agriculture for supporting exponentially growing population pesticides are used on an alarming scale. As these pesticides contain Organophosphorus (OP) compounds which are highly toxic and interfere with functioning of enzyme Acetylcholinestrase (AChE) and finally affecting Central Nervous System (CNS). So, there is an urgent need to monitor OP compounds concentration regularly in the marketed food products and even in the environment (water, soil). Here we focus on the different nanomaterials used for the fabrication of the AChE biosensors for detection of OP compounds which is based on inhibition of AChE. The merits and demerits of the different nanomaterials which are being used as supports are also discussed. The mode of detection, detection limit, linearity range, time of incubation, storage stability of the biosensors is also reviewed. Nanomaterial as an important class of supports used for the AChE biosensors due to their valuable properties. Among all the nanomaterials used Gold nanoparticles (AuNPs) have gained an advantage as they are explored with time.Â
Authors and Affiliations
Vikas Dhull, Neeraj Dilbaghi
Keywords
Related Articles
- EP ID EP579024
- DOI -
- Views 66
- Downloads 0
STABILITY OF FLOATING MICROSPHERES AT NORMAL AND ACCELERATED CONDITIONS
Objective: To study the stability profile of floating microspheres of repaglinide as per ICH guidelines under normal (25±2°C/60±5% RH) and accelerated condition (40±2°C/75±5% RH and 5-8°C/65±5% RH) for a period o...
THE PATENTED DRUGS UTILIZATION: A STUDY AT NGUYEN DINH CHIEU HOSPITAL IN BEN TRE PROVINCE FROM 2011 TO 2017
Objective: With their new and efficacious active ingredients, patented drugs have important roles in offering high-quality healthcare. However, huge cost-related barriers in accessing patented drugs along with the availa...
THE MODULATING EFFECT OF BARLEY β-GLUCAN EXTRACT ON HIGH FAT DIET INDUCED OBESITY-A BIOCHEMICAL STUDY IN ALBINO WISTAR RATS
Objective: Diet-inducedhyperlipidemia and obesity are the major risk factors for type II diabetes mellitus, hypertension, musculoskeletal and cardiovascular disorders (CVD). The objective of the present study is to furni...
A RAPID RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATIVE ESTIMATION OF EPLERENONE IN TABLETS
Objective: To develop a rapid, sensitive, accurate, precise, linear and rugged Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method and validate as per ICH guidelines for the quantitative estimation of...
CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC ANALYSIS OF BIOACTIVE COMPOUNDS FROM CAYRATIA TRIFOLIA (L.) STEM
Objective: The present study was to analyze the bioactive compounds from stem ethanolic extract of Cayratia trifolia by FTIR, HPTLC and GC-MS techniques.Methods: The FTIR was applied and infrared spectrum in mid-infrared...