Nanoscale Biomaterials for 3D printing
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 3
Abstract
Bio printing is an emerging tool for differentiating stem cells in 3D patterns. This technique provides the platform for regeneration of organs and tissues in a systematic manner.The use of suitable biomaterial with its crosslinking property on addition of a cross linker gives the exact structure with which we can grow stem cells into a specific tissue or organ. There exists a number of conventional biomaterials used as bioinks for 3D bioprinting and other biomedical applications, but due to its macro sized structure the applicability had been restricted to certain areas. In such cases nano-biomaterials play a key role in enhancing the physicochemical properties of existing biomaterials. Literature survey shows a wide range of conventional hydrogels available for printing and one can select these biomaterials according to the tissue to be regenerated. For example, regeneration of bone or cartilage requires relatively strong material and in such case soft materials will be inappropriate for the cells to differentiate into bone/cartilage tissue. Hence selection of biomaterial is one among the factors to be considered for tissue engineering. Here conventional biomaterials are not capable of fulfilling all the requirement of tissue engineering due its macro size and limited properties, therefore use of nanotechnology in the existing biomaterial can enhance the overall nature and bioactivity of the material. One more important factor influencing tissue regeneration is the use of bioinks. Bioinks not only protects the cells from external damage caused during fabrication but also helps in diffusion of nutrients and growth factors essential for cells differentiation and proliferation.As a prominent component of bio inks, hydrogels are commonly used in cell printing processes because of their low cytotoxicity and physical resemblance to the extracellular matrix (ECM). The review mainly focuses on the nanobiomaterials made from synergistic combinations of nanomaterials to overcome the shortcomings of existing biomaterials used as the bioinks, and make them suitable for various soft and hard tissue regeneration applications.
Authors and Affiliations
Akshay Bhatt1, Anand Anbarasu1
Keywords
Related Articles
- EP ID EP389790
- DOI 10.9790/3008-1203068086
- Views 92
- Downloads 0
Evaluating the Protective Impact of Ginger Extract Against Ciprofloxacin-Induced Hepatotoxicity in Male Albino rats
In the present study, potential protective impact of ginger extract against ciprofloxacin (CPFX)- induced hepatotoxicity in male rats was investigated. Forty-two adult male albino rats were divided into seven groups: con...
Biological Issues and Distribution of Mongolian Gerbil (Meriones Unguiculatus, Milne Edward, 1876) in Mongolia
Grasslands are the dominant landscape in Mongolia, accounting for 70-80 % of the national land area.Spreading of Mongolian gerbil distribution throughout the Mongolia including sandy desert, sandy steppe, steppe and fore...
Antiinflammatory activity of Flavonoids isolated from Rhus Mysorensis
Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecula...
Drug Control in Public Health Center through the Analysis of ABC Indexes Critical Drugs
Background: The use of drug in Indonesia reached 39% of the cost of healthcare, which many variations of drugs causes its utilization was inefficient. The study aimed to determine the critical index of drugs through anal...
Significance of Lactate Levels in Vaginal Fluid with Time of Spontaneous Onset of Labour in Suspected Cases of Pre-Labour Rupture Of Membranes
Background: Prelabour rupture of membranes is reported to occur in 2-25% of all pregnancies. The condition is associated with fetal and maternal infections, cord complications and might be marker of imminent delivery. It...