Nasal Drug Delivery-A Pre Hospital Therapy in Status EpilepsyReview
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Status epileptics is a brain disorder. It is an important neurological emergency with high mortality and morbidity. it causes loss of cerebral autoregulation and neuronal damage. Prompt and immediate prehospital treatment is required to shorten the duration of seizures. So Parents and care givers needssimple ,safe.,efficaciousprehospitaltherapy. As per parents and care givers needs and consideration of severity of status epileptics and complexity of brain this review has been focused on intra nasal route as a prehospital therapy. It is a potential route and alternative route for the administration of anticonvulsant drugs.It prevent the enzymatic or acidic degradation and first-pass hepatic metabolism. The nasal mucosa is one of the most permeable and highly vascularized site for drug administration ensuring rapid absorption and onset of therapeutic action.The objective of the review is provide information of status epileptics and its dangerous effects,need of rapid prehospitaltreatment, Factors to be considered in nasal drug delivery,new strategies of delivery of antiepileptic drugs by intra nasal route.
Authors and Affiliations
ChitraKarthikeyini. S . , K. Kavitha
Keywords
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- EP ID EP384521
- DOI 10.9790/3008-1103023946
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