Sedative, Analgesic and Cytotoxic activities of Nyctanthes arbor-tristis L.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
Nyctanthes arbor-tristis L. is a flowering plant widely distributed in Bangladesh as well as all over tropical and subtropical regions of Southeast Asia. It has been used in traditional medicine for its various pharmacological activities. This study evaluated the sedative, analgesic and cytotoxic activities of the ethanolic extract (NAE) and methanol extract (NAM) of Nyctanthes arbor-tristis L. leaves. Both the extracts showed significant sedative depressant property when assessed by thiopental sodium-induced sleeping time study and open field test at the doses 200 and 400 mg/kg (p.o.). Diazepam (1mg/kg, i.p.) was used as reference in both the experiments. The extracts also showed antinociceptive activity when determined using acetic acid-induced writhing test and formalin-induced paw licking test in mice at the doses 250 and 500 mg/kg (p.o.). Diclofenac sodium (40 mg/kg, p.o.) was used as reference analgesic drug. Brine shrimp lethality bioassay revealed that both extracts possess dose dependent cytotoxic activity. The ethanolic extract showed greater sedative, analgesic and cytotoxic activities than methanolic extract at all doses.
Authors and Affiliations
Ashfia Fatima Khan, Sabiha Akter, Marina Akter,, Md. Masum Billah, Jamil Azhar Shakil
Keywords
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