Nasopharyngeal Carcinoma in Pediatric Population: A Retrospective Analysis
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2014, Vol 16, Issue 1
Abstract
Nasopharyngeal carcinoma in pediatric patients is a rare malignancy. Majority of the patients present with locally advanced disease for which neoadjuvant chemotherapy followed by chemoradiation is the preferred regimen. A retrospective study was performed of 10 previously untreated pediatric nasopharyngeal carcinoma patients up to 14 years of age diagnosed and treated between 2010-2012. The histological diagnosis was made in all cases according to the World Health Organisation (WHO) classification. Overall response rate was seen in 87.5% of patients (7 out of 8 patients). Complete response seen in 3 out of 8 patients (37.5%). Partial response was seen in 4 out of 8 patients (50%). Out of 8 cases 7 developed mucositis (87.5); 4 (50%) had vomiting; 2 had febrile neutropenia (25%). Out of 8 patients 1 progressed (12.5%). Neoadjuvant chemotherapy followed by chemoradiation is a curative option in locally advanced nondistant metastatic nasopharyngeal carcinoma.
Authors and Affiliations
Akhil Jain, Apurva Patel, Asha Anand, Sandip Shah, Shilin Shukla, Bharat Parikh, shailesh Talati, Harsha Panchal, Sonia Parikh, Bhavesh Parekh, Shivani Bhatt
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