Natamycin treatment outcome in keratomycosis patients
Journal Title: Medpulse International Journal of Ophthalmology - Year 2018, Vol 5, Issue 2
Abstract
In this study, 50 fungal isolates from 50 patients with fungal keratitis were tested in vitro for their susceptibility to natamycin and the mean minimum inhibitory concentrations of natamycin (MICn) were correlated with clinical outcome. The mean MICn for various groups of fungi from patients with either early (<10 days) or late (≥10 days) presentation was correlated with the outcome. Aspergillus flavus showed resistance to natamycin with a high mean MICn (21 μg/ml). While the clinical response in all patients with early A. flavus keratitis was good it was poor in late cases. Fusariumspecies, Acremonium species were sensitive with low mean MICn (Fusarium: 7-9 μg/ml, Acremonium: 5-8 μg/ml. We conclude that despite susceptibility of most fungal species causing keratitis to natamycin, the treatment outcome is poor in advanced fungal keratitis.
Authors and Affiliations
Sukrit Pershad, Subhav Pershad, Nagababu Pyadala
Keywords
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