NATURAL HISTORY AND RESPONSES TO ANTIVIRAL THERAPIES FOR CHRONIC HEPATITIS B PATIENTS IN SUEZ CITY, EGYPT
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
Background: The natural history of chronic HBV infection is dynamic, involving a complex interplay between the virus, the hepatocyte and the host immune system. Aim: To improve the management plan of chronic hepatitis B. Patients and Methods: This is a retrospective descriptive study. It included 140 patients with chronic hepatitis B who were following up at the Communicable Disease Research and Training Center during the period between December 2010 and December 2015. Results: Most of patients were in the inactive carrier state representing about 70.2% while patients with active hepatitis represent only 22.8%. The incidence of reactivation was found to be 1.75%/year. Concerning liver cirrhosis; its prevalence was found 18.6% while its incidence was 1.1%/ year. The cumulative 5-years resistance rate to the antiviral drugs was as the follow: Lamivudine (23.9%) while Lamivudine + Adefovir regimen (50%), however no detected resistance for tenofovir. Conclusion: Chronic hepatitis B has a relatively benign course in our region, however regular follow up is recommended due to its dynamic nature and for early detection of its devastating complications. Lamivudine has a fair response rate in our region, unfortunately the response rate to the Adds-On regimen with adefovir was found disappointing, however Tenofovir was found to be highly efficient.
Authors and Affiliations
Mohamed Mosaad
Keywords
Related Articles
- EP ID EP674663
- DOI -
- Views 157
- Downloads 0
PHYTOCHEMICAL ANALYSIS, ANTIOXIDANT AND IN VIVO ANTINEOPLASTIC PROPERTIES OF CARICA PAPAYA FRUITS
Oxidative stress, based on imbalance between pro-oxidants production and antioxidant defenses is involved in several human chronic diseases such as cancer, diabetes mellitus and coronary heart disease. This study sought...
FREQUENCY OF CHOLELITHIASIS - RELATED COMPLICATIONS IN MALE GENDER ATTENDING SURGICAL DEPARTMENT AT KING KHALID GENERAL HOSPITAL, MAJMAAH, KSA
Introduction: Gallstone disease known as cholelithiasis is one of the most common Biliary Tract disorder. Cholelithiasis is common with the incidence ranging from 10% to 20% of the world population, 11% of the general po...
CLINICAL EFFECTS OF TRIPHALA GUGGULU ON DIABETIC MACULAR EDEMA
Diabetic macular edema (DME) is the largest cause of visual acuity loss in Diabetes. It mainly affects the central vision from early stages of retinopathy, and it is the most common sight-threatening complication of diab...
ANTIOXIDANT ACTIVITY OF SEQUENTIALLY EXTRACTED SOLVENT EXTRACTS OF CYNODON DACTYLON GROWING IN COASTAL AREA OF BANGLADESH
The present study was focused on the antioxidant activity of sequentially extracted different solvent extracts of C. dactylon growing in coastal area of Bangladesh. Powdered plant materials were continuously extracted wi...
FORMULATION AND EVALUATION OF GEMIFLOXACIN INTRA-POCKET FILM FOR PERIODONTITIS
In the present investigation, an effort was made to design a novel drug delivery system for the treatment of chronic periodontitis for site-specific delivery of Gemifloxacine mesylate which has excellent activity against...