Naturalne i syntetyczne laktony o aktywności przeciwnowotworowej i przeciwdrobnoustrojowej
Journal Title: Wiadomości Chemiczne - Year 2011, Vol 65, Issue 1
Abstract
Medicine is one of the most developing branches of knowledge. But even now there are still some diseases which are impossible to cure. Different cancers, antibiotic resistant bacterial infections and fungal pathogenesis infections are still everlasting problems. Thus, two ways of solutions are proposed. First is the return to natural medicines. From the ancient times plants have been used in medicine and the natural products have been an important source of drugs. Nowadays isolation and identification of these compounds, together with the determination of their biological activity, also play an important role. Lactones are the cyclic esters with a wide range of carbon atoms in a lactone ring. They are a very interesting group of compounds which reveal a wide spectrum of biological activity. Terpenoid, especially sesquiterpene lactones and coumarin derivatives, are found in plants of the Asteraceae and Apiaceae families as well as in many others organisms. The naturally occurring lactones often possess anti-inflamatory [1, 2], phytotoxic [3, 4], antiprotozoal [5], and antiviral activities [6]. They are also well known for their anticancer [7, 8] and antimicrobial activities [9, 10]. The second way of obtaining new biologically active lactones is the chemical synthesis of new potent structural analogs of natural bioactive compounds. However, the complexity of natural products and their derivatives may lead to limited supplies, especially when they have the chiral centers which are one of the most important factors influencing their biological activity. It also causes difficulties to determine the mechanism of action. For those reasons, structural simplification plays an important role in the development of analog design. This review is focused on novel literature data about synthetic and natural lactones which reveal anticancer, antibacterial and antifungal activities. Presented compounds show potent biological activity and high selectivity with holding promises for further applications.
Authors and Affiliations
Marcelina Mazur
Keywords
Related Articles
- EP ID EP591209
- DOI -
- Views 129
- Downloads 0
Krytyczne stężenie micelarne i metody jego wyznaczania
Surfactants are substances, which have surface activity in aqueous solutions [1–3]. By adsorbing on the surface (boundary of phase separation) of the system, they change the surfactant properties of the liquid. Surfactan...
Spektrometria mas w analizie białek i peptydów : znaczniki jonizacyjne
High sensitivity, accuracy, and ability to provide structural information makes mass spectrometry (MS) the method of choice for both qualitative and quantitative analysis in proteome research. Peptide sequencing by tande...
Farmakologiczna aktywność flawonoidów i aminoflawonów
Aminoflavones belong to a group of flavonoids, compounds commonly found in nature. Their pharmacological and biochemical effects include cytotoxic, antioxidant and antitumor properties. The studies have shown that comple...
Charakterystyka mocy poszczególnych wiązań wodorowych w parach zasad DNA
The main idea of the current review is to present methods useful to characterize the strength of individual hydrogen bonds in nucleic acids base-pairs. In the paper, the Authors discuss the energy definition of intermole...
Sieciowanie samoprzylepnych klejów silikonowych
Pressure-sensitive adhesives (PSAs) represent a system that actually dates back to the invention of the self-adhesive articles in 1935 when R. Stanton Avery produced the first coating unit using a wooden cigar box with t...