A CLINICOPATHOLOGICAL STUDY OF NEUROFIBROMATOSIS TYPE 1 IN A TERTIARY LEVEL CARE CENTRE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 52
Abstract
BACKGROUND Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder, and its diagnosed with a set of clinical criteria and histopathological examination of skin lesions. This study was designed to evaluate the clinical and pathologic pattern of NF1 among patients attended OPD in Chengalpattu Medical College. METHODS AND MATERIALS A retrospective clinical and histopathological case study of 50 patients diagnosed as NF1 were studied over a period of 1 year (April 2014-March 2015) at Chengalpattu Medical College. RESULTS 50 patients were taken up for study with 31 males and 19 females (ratio 3:2) aged 1-99 (Mean±S.D. = 3.4±1.7) years. All patients had neurofibromas, and were benign, while 49 (99%) patients had cafe-au-lait spots. Benign neurofibromas were clinically cutaneous [38 (76%)], subcutaneous [9 (18%)], segmental [1 (2%)] and plexiform [2 (4%)]. Sites of distribution of neurofibromas included the extremities (50%), trunk (30.4%), head and neck (9.4%), and other sites (10.2%). CONCLUSIONS In our setting, NF1 is more common among males, with the highest density of neurofibromas covering the extremities and trunk.
Authors and Affiliations
Hema , Sindhuja , Vanathi , Sridhar , Vijayabhaskar , Murugan , Sarath B. , Prathyusha
Keywords
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- EP ID EP96323
- DOI 10.14260/jemds/2016/792
- Views 71
- Downloads 0
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