A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro

Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2

Abstract

 A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs’ platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β- amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.

Authors and Affiliations

Ali Ali El Gamal , Mohamed Farag Abd El Halim , Ashraf Taha Kalil , Omer Ahmed Basudan , Adnan Jathlan Al-Rehaily , Mohamed Shamim Ahmad , Kamal Hussin El Tahir , Shaza Mohamed Al-Massarani , Wael Moustafa Abdel-Mageed¬

Keywords

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  • EP ID EP89346
  • DOI -
  • Views 112
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How To Cite

Ali Ali El Gamal, Mohamed Farag Abd El Halim, Ashraf Taha Kalil, Omer Ahmed Basudan, Adnan Jathlan Al-Rehaily, Mohamed Shamim Ahmad, Kamal Hussin El Tahir, Shaza Mohamed Al-Massarani, Wael Moustafa Abdel-Mageed¬ (2015).  A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro. Pakistan Journal of Pharmaceutical Sciences, 28(2), 745-753. https://europub.co.uk/articles/-A-89346