A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs’ platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β- amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.
Authors and Affiliations
Ali Ali El Gamal , Mohamed Farag Abd El Halim , Ashraf Taha Kalil , Omer Ahmed Basudan , Adnan Jathlan Al-Rehaily , Mohamed Shamim Ahmad , Kamal Hussin El Tahir , Shaza Mohamed Al-Massarani , Wael Moustafa Abdel-Mageed¬
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