Albumin versus fresh frozen plasma in managing diuretic resistant edema in children with idiopathic nephrotic syndrome
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 7
Abstract
ABSTRACT: This study was carried out to compare the efficacy, cost effectiveness and outcome of albumin with fresh frozen plasma (FFP) in the treatment of diuretic resistant edema in childhood idiopathic nephrotic syndrome.Methods: Fifty four patients with idiopathic NS were enrolled in this prospective analytic study. Patients with moderate to severe edema with serum albumin <15 gm/L were given albumin and FFP dividing into two groups. Group-A, received intravenous albumin- 1 gm/kg/day and Group-B intravenous FFP 15ml/kg/day. Total number of albumin and FFP infusion were determined by edema reduction. Cost effectiveness was also calculated. Results: Diagnosis of NS and biochemical parameters were same in both groups. Dry weight was achieved in Group-A in 6.66± 3.710 days and in Group-B 6.66± 3.038 days. In GroupA the number of albumin infusion required was 1.44±0.697 and Group-B FFP infusion required was 3.11± 1.5 (p=0.0001). Group A needed 4608.00 ($57.6) taka for albumin whereas Group B needed only 2177.00($ 27.2) taka for FFP (p=0.0001). No significant complications were observed in both the groups.Conclusion: FFP costs half than albumin and same duration required reducing edema but the cost-effectiveness may place FFP as a better choice especially in developing countries of the world.
Authors and Affiliations
Dr. RanjitRanjan Roy , Dr. Abdullah Al Mamun , Dr. Syed Saimul Haque3 , ,Dr. Avro Mitra , Dr. Golam Muinuddin , Dr. Md. Habibur Rahman Professor, Department of Pediartic Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Keywords
Related Articles
- EP ID EP153387
- DOI -
- Views 112
- Downloads 0
Factors Favouring Cholelithiasis in North Indian Population
The present study was done on 132 cases those underwent cholecystectomy for benign Gall Bladder disease. Our study concluded that maximum ,58 cases(43.94%) number of cases were in the age group of 41-50 years fol...
Antibiotic resistance patterns of methicillin-resistant Staphylococcus aureus (MRSA) isolated from chronic skin ulcer of patients in Kaduna state, Nigeria.
The aim of this study is to investigate the antibiotic resistance patterns of methicillin - resistant Staphylococcus aureus (MRSA) isolated from out - patients with chronic skin ulcer in four different ho...
Evaluation of Aframomum melegueta aqueous seed extract on food and water consumption in albino rats
ABSTRACT:- This experiment was carried out to evaluate the effect of seed extract of Aframomum melegueta on water and feed intake in albino rats. The aqueous seed extract of Aframomum melegueta was administered (p.o) to...
Isolation and NMR Spectral Assignments of 18-Glycyrrhetinic acid-3-O-D-glucuronide and 18-Glycyrrhetinic acid
Two olenane triterpenes, 18β-glycyrrhetinic acid-3-O-β-D-glucuronide and 18β-glycyrrhetinic acid were obtained from the acid hydrolysis of 18β-glycyrrhetinic acid-3-O-β-D-glucuronopyranosyl-(1→2)-β-D-glucuronide...
Assessment & Evaluation of the Outcome for Closed and Open Method in Treatment of Segmental Tibial Fracture
Segmental tibial fractures are considered to be a special type of injury associated with high complication rates and are defined by the presence of two or more distinct fracture lines with completely isolating an...