Allopurinol improves endothelial function and oxidative stress in patients with chronic kidney disease.
Journal Title: Journal of Medical Science and Technology - Year 2013, Vol 2, Issue 1
Abstract
In uremia, mechanistic alterations of vessel wall properties, which have a profound impact causing decreased arterial compliance or its inverse; increased arterial stiffness, early wave reflections and decreased endothelial function. Allopurinol an xanthine oxidase inhibitor, has been found to improve endothelial function in patients with hypercholesterolemia, diabetes mellitus and heart failure. Twenty five Patients with chronic kidney disease in the age group between 20 to 60 years were enrolled into allopurinol study. Reflection index (RI), Serum Malondialdehyde (MDA) and Total antioxidant activity (TAA) were estimated before and after treatment with allopurinol. Allopurinol significantly lowered serum uric acid concentrations from 487 119 to 384 101 µmol/L, P<0.01 and serum MDA from 108 27 to 87 32 nmol/L, P<0.01. Allopurinol independently of renal functions; improves endothelial function, probably through either uric acid lowering effect or improving
Authors and Affiliations
Pathapati Rama Mohan
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