Comparison of creatinine clearance in HIV/AIDS patients on Tenofovir and two non Tenofovir based NRTIs after one year of therapy.
Journal Title: Journal of Medical Science and Technology - Year 2015, Vol 4, Issue 2
Abstract
The main objective was to compare the Creatinine Clearance (CLcr) in HIV/AIDS patients on treatment with Tenofovir (TDF) based regimen to those on non- TDF- based regimen (Stavudine (D4T) and Zidovudine (AZT) after 1 year of initiation of therapy. An analytical cross- sectional designed was applied to data on files of 275 HIV/AIDS patients on TDF and 274 HIV/AIDS patients on either D4T or AZT making a total of 549 files. The median age of participants in the study group was 29 years (Q1:19 years, Q3: 35 years) while the median age of participants on D4T or AZT was 20 years (Q1:17 years, Q3: 30 year). CLcr was calculated at baseline and at 1 year of therapy using the Cockcroft- Gault formula from the Serum Creatinine (SCr), weight, age and gender of the patients. There was no significant difference between themedian baseline CLcr in the study group and control group and both were in the normal CLcr range according to Kidney Disease Outcome Quality Initiative (K/ DOQI) criteria; 99.39 mL/min verses 104.58 mL/min, P= 0.0574. It was also found that more patients on TDF developed abnormal creatinine clearance at 1 year from normal baseline kidney function compared to those on either D4T or AZT; 51 vs. 8. In logistics regression it was found that treatment with TDF increased the odds of developing abnormal kidney function to 8.77 times compared to AZT or D4T; P<0.001. Gender was not associated with increased odds of abnormal CLcr while with every unit increase in age, the odds of increased by 1.07, P= 0.001. In conclusion, treatment with TDF increased the odds of developing abnormal CLcr at 1 year of treatment from having normal CLcr at baseline and increase in age was associated with developing abnormal CLcr in treatment with TDF.
Authors and Affiliations
Freeman Chabala, Gibson Sijumbila, Aggrey Mweemba, Mwenya Kwangu, kasonde Mpanga, Njeleka Banda, Soka Nyirenda
Keywords
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