AN REVIEW ON (SMEDDS) SELF MICRO-EMULSIFYING DRUG DELIVERY SYSTEM
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2015, Vol 5, Issue 1
Abstract
ABSTRACT In pharmaceutical solubility is one of the biggest problem to formulate the suitable dosage form because according to new chemical (drug) entities around 40% drug exhibit poor aqueous solubility and low bioavailability. The bioavailability of poor water soluble drugs may be enhanced when co-administered with meal rich in fat has led to increasing recent interest in the formulation of poorly water soluble drugs in lipids. Novartis Pvt. Ltd. Neoral TM (Cyclosporine A), and Fortovase (Saquinavir), Roche Laboratories Inc. much focused on self micro-emulsifying drug delivery systems (SMEDDS). SMEDDS are surfactant, isotropic mixtures of oil, co-surfactant and drug with a unique ability to form fine oil in water micro emulsion upon mild agitation following dilution with aqueous phase. The hypothesis behind dissolution rate enhancement with SMEDDS is the spontaneous formation of the emulsion in the gastrointestinal tract which presents the drug in solubilized form, and the small size of the formed droplet provides a large interfacial surface area for drug absorption. Keywords: SMEDDS, Biopharmaceutical Aspects, Excipients.
Authors and Affiliations
DK Sanghi and Rakesh Tiwle*
Keywords
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