PREVALENCE AND VARIATION IN REDUCED SUSCEPTIBILITY PATTERN OF NOSOCOMIAL MRSA ISOLATES TO VANCOMYCIN
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 4
Abstract
ABSTRACT Staphylococcus aureus plays a vital role in hospital-acquired infection. It has overcome most of the antibiotics in the recent years. Their poly-antimicrobial resistance should be noticed carefully and dealt-with caution. Methicillin-Resistant Staphylococcus aureus (MRSA) is a multidrug resistant group and are ubiquitous in the hospital environment. Vancomycin is a drug of choice for treating severe MRSA infections. However, the recent reports pointed about the reduction in the susceptibility to vancomycin observed among MRSA isolates. In our present study, an attempt was made to study the vancomycin susceptibility pattern of MRSA isolates from nosocomial infections during the period of October 2012–March 2013 and came out with fruitful results. Three isolates BS3, BS5 and SS2 showed intermediate sensitivity to vancomycin (VISA MIC 4–5µg/ml).The present study revealed the presence of MRSA with increasing vancomycin Minimum Inhibitory Concentration (MIC).This alarming result represents determination of MIC for vancomycin is necessary before starting the treatment for MRSA infections. Keywords: MRSA; Vancomycin; MIC; Nosocomial infections.
Authors and Affiliations
Uma C* and Sivagurunathan P
Keywords
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